In
a
head-to-head
study,
Simparica
Trio®
outperformed
NexGard® PLUS
against
the
drug
resistant
heartworm isolate
The
study
assessed the
efficacy
of both
parasiticides
against
the
macrocyclic-lactone drug
resistant
heartworm
isolate
ZoeLA
after
6 consecutive
monthly
doses.
Adult
Worm
Counts
Geometric
Mean
Moxidectin
Dose
(Range)
37.9
(24.11
-
47.78)
17.6
(14.78
-
from
necropsy
examination.
Geometric
mean counts
with different
superscript
are
<
0.05).
-
Simparica
or
NexGard PLUS
vs,
Placebo: 0.0001
Simparica
Trio
vs.
NexGard PLUS:
P
=
0.0316
INDICATIONS
Simparica
Trio is
indicated for the
prevention
of heartworm disease caused
by
Dirofilaria
immitis
and
for the treatment and control of roundworm
(immature
adult and adult
Joxocara
canis and
adult
Joxascaris
and hookworm
(L4,
immature
adult,
and adult caninum and
adult
Uncinaria
infections.
Simparica
Trio
kills adult fleas
(Ctenocephalides
felis)
and
is
indicated for the treatment and
prevention
of flea
infestations,
the
prevention
of
Dipylidium
caninum (tapeworm) infections
as a
direct result of
killing
Ctenocephalides felis vector fleas
on
the
treated
dog,
and the treatment and control of tick infestations with
Amb/yomma
americanum
(lone
star
tick),
maculatum
(Gulf
Coast
tick),
Dermacentor variabilis
(American dog
tick),
scapularis
tick),
Rhipicephalus
sanguineus
(brown
dog
tick),
and
Haemaphysalis longicornis
(Asian
longhorned
tick)
for
one
month
in
dogs
and
puppies
8 weeks of
age
and
older,
and
weighing
2.8
pounds
or
greater.
Simparica
Trio is indicated for the
prevention
of Borrelia
burgdorferi
infections
as a
direct result of
killing
scapularis vector ticks.
IMPORTANT SAFETY INFORMATION
Use
with
caution
in
dogs
with
a
history
of
seizures.
Simparica
Trio contains
sarolaner,
a
member of
the isoxazoline class which has been associated with
neurologic
reactions
including
tremors,
ataxia,
and seizures
in
dogs
with
or
without
a
history
of
neurologic
disorders. The safe
use
of
Simparica
Trio
has not been evaluated
in
breeding,
pregnant,
or
lactating dogs.
The
most
frequently
reported
adverse reactions
in
clinical trials
were
vomiting
and diarrhea. See full
Prescribing
Information at
References:
1. Bata
on
file,
Study
Zoetis
Inc.
2.
TL,
Six
RH,
A
et al. 2019. Parasit
Vectors.
3.
Myers
JAE,
Holzmer MeCall et
al.
2022. Parasit
Vectors.
4. NexGard* PLUS
[package
insert).
NexGard® PLUS
is
a
trademark of
Boehringer Ingelheim
Animal Health
France,
used under license.
SNAP is of
All
trademarks
are
the
property
of Zoetis Services LLC
or
a related
company
or
a
licensor unless otherwise noted.
2026 Zoetis Services.
All
rights
reserved.
of
Dogs
withAdult
Number of
Antigen
Positive
Dogs!
Percent reduction
compared
to
§
SNAP* Heartworm
RT
Stunted female
worm
recovered from abdominal
cavity,
Number
of
Dogs
with
Microfilariae
|
Days
of
Treatment
0, 30, 60,
90, 120,
150
0, 30,
90, 120,
150
30. 60.
90,120
Treatment
Individual
Heartworm
Counts
26, 35,
38,
42,45
0,
Percentage
Pet-Tabs
(Placebo)
Simparica
Trio
NexGard PLUS
