HD Insights™

HD INSIGHTS TM EDITOR' S WELCOME Welcome to the first edition of HD InsightsTM! Our mission is to promote, disseminate, and facilitate research in Huntington disease by producing content that will be valuable and informative to the global community of HD researchers in academia and industry. To fulfill this mission, we have assembled a distinguished editorial board, outstanding writers, and a first rate production team. The editorial board represents four continents and has representatives of academia, industry, and the HD community. Our writers are some of the rising stars in HD research, and our production team has creative and dedicated individuals with diverse talents. In each issue, we will bring you insights from the leading scientists, innovators, and companies developing therapeutics for HD. In addition, we will keep you current on the emerging science, the proceedings from major HD meetings, and clinical trials in the field. The genesis of HD InsightsTM came from the Huntington Study Group, which saw a need to disseminate research in the field, and from Lundbeck, which provided a generous unrestricted educational grant to help launch this periodical. In our first year we plan on producing three issues timed to national and international meetings of HD researchers. To receive a free subscription to HD InsightsTM, simply email subscribe@hdinsights.org with your name and organization. All of our content as well as bios and disclosures are available online at www.hdinsights.org. As a new periodical aimed at meeting the needs of our readers, we are especially interested in your thoughts and suggestions for people to interview, events to cover, and ideas to explore. Also as a new periodical, we are eager to secure support to make HD InsightsTM an enduring periodical that informs and motivates over 1000 scientists, physicians, and drug developers specifically interested in HD. support, please contact me at editor@hdinsights.org. Together we can advance research and eventually therapeutics for Huntington disease. -- RAY DORSEY, MD EDITOR, HD INSIGHTSTM If you have ideas, want to contribute, or are eager to Editorial Board Members Ray Dorsey, MD — Editor, Johns Hopkins University Donald Kennedy, PhD — Stanford University Nobuyuki Nukina, MD, PhD — Riken Brain Science Institute Rodrigo Osorio — Agrupacion Chilena de Huntington Bernard Ravina, MD — Biogen Idec Ralf Reilmann, MD — University of Munster Sarah Tabrizi, MBChB, PhD — University College London Leslie Thompson, PhD — University of California Irvine Huntington Study Group Shari Kinel, JD — HSG Executive Director Liz McCarthy, BA — HSG Administrative Manager Jillian Lowell, BS — HSG Event Planner Contributors Emily Fisher Alicia Semaka, M.Sc. Mahmoud Pouladi, PhD Lise Munsie Kristin Darwin, BS Paige Nichols, BA Publication Staff Robin Taylor — Production Editor Martin Holmes — Technical Editor Todd Bernhard — Copy Editor Vinayak Venkataraman, BS — Website Designer Dave Kolko — Distribution Specialist 12 For more information on HD InsightsTM, please visit us at www.HDInsights.org Copyright © Huntington Study Group 2011. All rights reserved. HD InsightsTM, Vol. 1

• Cover