HD Insights™

Volume 2

Issue link: http://www.e-digitaleditions.com/i/56063

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A Huntington disease re s e a rc h Research Round-up Lise Munsie and Mahmoud Pouladi, PhD review the latest HD developments in imaging, basic research and clinical research. Page 3 2011 HSG Meeting in Indianapolis, Indiana David Shprecher, DO MS recaps highlights from the 2011 Huntington Study Group meeting and Fifth Annual Clinical Research Symposium. Page 4 HD Insights periodical Issue No 2 - Winter 2012 Meet the Journal Blair Leavitt, MD and Leslie Thompson, PhD discuss the new Journal of Huntington's Disease. Page 7 Status Report: Clinical Trials At-a-glance updates on clinical trials in HD Page 5 Inside the NINDS with Dr. Walter Koroshetz Dr. Walter Koroshetz became Deputy Director of the National Institute of Neurological Disorders and Stroke (NINDS) in 2007. He received his medical degree from the University of Chicago and trained in neurology at Massachusetts General Hospital (MGH). After completing his residency, he was introduced to the HD Center without Walls at MGH and Boston University. He started seeing patients with HD and became involved in the first pre-symptomatic testing for HD. Dr. Koroshetz was also involved in early HD imaging research, and helped discover the effect of HD on lactic acid levels in the brain.1 At the 2011 Huntington Disease Clinical Research Symposium in Indianapolis, Indiana, Dr. Koroshetz sat down with HD INSIGHTS to discuss his role as Deputy Director of NINDS and the NIH's new project, NeuroNEXT. INSIGHTS: What motivated your transition from academia to the NIH? KOROSHETZ: I was at a point in my career where I had done a bunch of things, and there were a number of leadership opportunities opening up. One of them happened to be this job at the NIH, which I thought was unique. There's only one Deputy Director of NINDS in the country, and you get an experience that is quite unique, that no one else really sees. You get to see neuroscience, neurology, policy and government from a unique vantage point. INSIGHTS: Has it been interesting? KOROSHETZ: Yes. It's like being a kid in a candy shop. If you're interested in all sorts of different neurologic issues, it's the best place to be because you see everything. I may have meetings on three different diseases in one day. If you have ADHD for neurology, it's a great job! INSIGHTS: Were there any drawbacks? KOROSHETZ: There's clearly a big difference when you go from being in an academic institution to being in an administrative job in government. So I certainly miss a lot of the interactions I had with patients, young physicians, residents, fellows, colleagues in the trenches. There's nobody really in the trenches with me anymore. I'm kind of there by myself. (continued on Page 2...) 1. Jenkins BG, Rosas HD, Chen YC, Makabe T, Myers R, MacDonald M, Rosen BR, Beal MF, Koroshetz WJ. 1H NMR spectroscopy studies of Huntington's disease: correlations with CAG repeat numbers. Neurol. 1998; 50(5): 1357-65. HD Insights, Vol. 2 Copyright © Huntington Study Group 2012. All rights reserved. 1 Walter Koroshetz, MD TM

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