Inhalation

INH0617

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7. United Nations Environmental Programme. June 2015 Report of the technology and economic assessment panel, Volume 1. [Cited Apr 27, 2017] Available at: http://ozone.unep.org/en/teap-june-2015-progress- report-volume-1. 8. World Health Organization. Life expectancy increased by 5 years since 2000, but health inequalities persist. [Cited Apr 27, 2017] Available at: http://www.who.int/mediacentre/news/releases/2016/health-inequalities- persist/en/. 9. World Health Organization. Chronic obstructive pulmonary disease (COPD). [Cited Apr 27, 2017] Available at: http://www.who.int/media centre/factsheets/fs315/en/. 10. Taffet GE, Donohue JF, Altman PR. Considerations for managing chronic obstructive pulmonary disease in the elderly. Clin Interv Aging. 2014;9:23-30. 11. Winningham RE. Theravance Biopharma. Presented at: 14th Annual Needham Healthcare Conference, New York, NY, US, April 2015. [Cited Feb 20, 2017] Available at: www.sec.gov/Archives/edgar/data/1583107/ 000110465915027343/a15-9036_1ex99d1.htm. 12. Pritchard JN. Industry guidance for the selection of a delivery system for the development of novel respiratory products. Expert Opin Drug Deliv. 2015;12(11):1755-1765. 13. Welch MJ. Nebulization therapy for asthma: A practical guide for the busy pediatrician. Clin Pediatr. 2008;47(8):744-756. 14. Slator L, Parker J, Hardaker L, Potter R. Assessment of delivered dose rate from 2 mesh nebulizers tested with an adult breathing pattern and 2 drugs. Presented at: Drug Delivery to the Lungs Conference 27, Edin- burgh, Scotland, UK, December 7-9, 2016. 15. Hatley RHM, Hardaker LEA, Metcalf AP, Parker J, Quadrelli F, Pritchard JN. Ensuring the consistency of performance of mesh nebulizers. Presented at: Drug Delivery to the Lungs Conference 27, Edinburgh, Scot- land, UK, December 7-9, 2016. 16. Hatley RHM, Rowe L, Rabbetts I, Quadrelli F. Optimizing patient experience of nebulizer treatments. Eur Respir J. 2016;48:PA4082. 17. Rottier BL, van Erp CJP, Sluyter TS, Heijerman HGM, Frijlink HW, and de Boer AH. Changes in performance of the pari eFlow rapid and pari LC plus during 6 months use by CF patients. J Aerosol Med Pulm Drug Deliv. 2009;22:1-7. 18. Aerogen pioneering aerosol drug delivery. Clinical white paper. [Cited Apr 27, 2017] Available at: https://www.aerogen.com/products/aerogen- ultra/. 19. Ingram H: Nebulisers—World—2014 . IHS Technology; 2014 [Cited Feb 20, 2017] Available at: https://technology.ihs.com/ 435839/nebulizers-2014. 20. Degtyareva Y, Metcalf A, Hardaker LEA, Pritchard JN, Hatley, RHM, Efficiency of the Micro mesh nebulizer tested with three different fill vol- umes. In: Dalby RN, Byron PR, Peart JD, et al. editors. Respiratory Drug Delivery Europe 2015. Davis Healthcare International; River Grove, IL: 2015. p. 401-404. 21. Usmani OS, Biddiscombe MF, Barnes PJ. Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size. Am J Respir Crit Care Med. 2005;Dec 15;172(12):1497-1504. 22. Darquenne C. Aerosol deposition in health and disease. J Aerosol Med Pulm Drug Deliv. 2012;25(3):140-147. 23. Haworth CS, Foweraker JE, Wilkinson P, Kenyon RF, Bilton D. Inhaled colistin in patients with bronchiectasis and chronic Pseudomonas aeruginosa infection. Am J Respir Crit Care Med. 2014;189(8): 975-982. 24. Pritchard JN, von Hollen D, Hatley RHM. The utility of monitoring inhaled drug adherence and technique in clinical trials. In: Dalby RN, Byron PR, Peart JD, et al. editors. Respiratory Drug Delivery Europe 2015. Davis Healthcare International; River Grove, IL: 2015. p. 413-417. 25. ClinicalTrials.gov. Search for Studies. [Cited Apr 27, 2017] Available at: https://clinicaltrials.gov. 26. clinicaltrialsregister.eu. Clinical Trials Search. 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European Committee for Standardization (CEN): EN 13544-1: 2007+A1:2009. Respiratory therapy equipment: Nebulizing systems and their components. European Committee for Standardization; 2010. 33. ISO 27427:2013(E), Anaesthetic and respiratory equipment—Nebu- lizing systems and components. 34. Hatley RHM, Byrne SM. Variability in delivered dose and respirable delivered dose from nebulizers: Are current regulatory testing guidelines sufficient to produce meaningful information? Med Devices (Auckl) 2017;10:17-28. 35. World Health Organization: Adherence to long-term therapies: Evi- dence for action. World Health Organization, Geneva, Switzerland, 2003. 36. Mularksi R, McBurnie MA, Donovan JR, Walker KL, Gillespie SE, Vollmer WM. Adherence with inhaled respiratory therapeutics is associ- ated with reduced acute exacerbations of chronic obstructive pulmonary disease. Eur Respir J. 2011;38:(Suppl 55):4868. 37. Bollu V, Ernst FR, Karafilidis J, Rajagopalan K, Robinson SB, Braman SS. Hospital readmissions following initiation of nebulized arformoterol tartrate or nebulized short-acting beta-agonists among inpatients treated for COPD. Int J Chron Obstruct Pulmon Dis. 2013;8: 631-639. 38. Pritchard JN. Rethinking the paradigm for the development of inhaled drugs. Int J Pharm. 2015; 496(2): 1069-1072. 39. Loenner M, Gallem T, Hetzer U, inventors; Pari Pharma GmbH, assignee. Disposable ampoule for an aerosol generating device. United States patent US 9,265,900 (B2). Filed Nov 21 2008; issued Feb 23 2016. 16 JUNE 2017 Inhalation Click to read the remainder of the references.

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