Issue link: https://www.e-digitaleditions.com/i/1000772
24 July 2018 Tablets & Capsules Issue focus excipients & formulation Rice-based lubricant Nu-Mag excipient provides a natural alternative to magnesium stearate and stearic acid in formulations that require a lubricant. Free-flowing fine powder—made from rice extract, rice hulls, gum arabic, and sunflower oil— helps dietary supplements achieve clean-label status. Third-party ejection force tests show that the rice-based excipient used at 1 percent provides the same level of tablet lubrication as stearic acid used at 0.5 percent. Excip- ient contains no GMOs or gluten and is certified organic and kosher. Ribus, St. Louis, MO 314 727 4287 www.ribus.com Bioavailability-enhancing excipients Company develops and manufactures lipid-based excipients to enhance the bioavailability of poorly water-soluble and poorly permeable APIs. Offerings i n c l u d e C a p m u l b i o a v a i l a b i l i t y enhancers, which are medium-chain mono- and diglycerides and propylene glycol esters that act as solubilizers and emulsifiers in oral drug delivery systems. Functional lipid excipients are a suitable starting point for formulating BCS Class II and IV (poorly water-soluble) and BCS Class III and IV (poorly permeable) molecules. Company's lipid-based drug delivery systems may be formulated as liquid or semi-solid formulations. Abitec, Columbus, OH 614 429 6464 www.abiteccorp.com High-purity chemical salts Company manufactures high-purity chemical salts for the pharmaceutical, biopharmaceutical, and nutritional mar- kets at its FDA-registered, cGMP bulk pharmaceutical-compliant site. Products meet ICH, USP, EP, ACD, and FCC requirements; are BSE/TSE-, GMO-, and allergen-free; are kosher- and halal-certified; are consistent lot-to-lot; and contain less than 1 part per million of lead, arsenic, cad- mium, mercury, and aluminum. Portfolio of more than 250 chemical salts includes acetates, carbonates, citrates, gluconates, fuma- rates, lactates, nitrates, phosphates, and sulfates. Products can be supplied in various particle sizes from granular free-flowing salts to ultrafine powders smaller than 6 microns. Packaging options include plastic pails, fiber drums, fiber cartons, and bulk super sacks. Jost Chemical, St. Louis, MO 314 428 4300 www.jostchemical.com Gelatin for softgels Company offers many gelatin types to achieve different release profiles, including RXL gelatin that reduces cross-linking and speeds release of fill. Company's EC gelatin allows for one- step production of clear enteric capsules using existing equipment. Enteric gela- tin reduces production time and cost by eliminating the need to coat fresh soft- gels with an acid-insoluble film coating, which is opaque and less desired by consumers. It also minimizes the effects of ingesting fish oil and other omega-3 fatty acids, including fishy burps and aftertastes. Capsules comply with USP dissolution parameters. Gelita USA, Sergeant Bluff, IA 800 223 9244 www.gelita.com