Tablets Capsules

TC0918

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22 September 2018 Tablets & Capsules 4. J. Kushner and F. Moore, "Scale-up model describ- ing the impact of lubrication on tablet tensile strength," International Journal of Pharmaceutics, Vol. 399, pages 19-30. 5. Paul J. Sheskey, Walter G. Cook, and Colin G. Cable, Handbook of Pharmaceutical Excipients, 8th edition, Pharmaceutical Press, 2017. 6. K. Pingali, R. Mendez, D. Lewis, B. Michniak- Kohn, A. Cuitino, and F. Muzzio, "Mixing order of gli- dant and lubricant—Influence on powder and tablet properties," International Journal of Pharmaceutics, Vol. 409, pages 269-277. Sayantan Chattoraj is a senior scientific investigator in drug product design and development at GlaxoSmithKline, Patrick Daugherity is a principal scientist in drug product design at Pfizer, Todd McDermott is director of process engineering sci- ences at AbbVie, Angela Olsofsky is a senior associate scientist in drug product technologies at Amgen, Wyatt J. Roth is a senior research scientist in small molecule design and develop- ment at Eli Lilly, and Mike Tobyn is a research fellow at Bristol-Myers Squibb. The IQ Consortium is a technical- ly-focused organization of pharmaceutical and biotechnology companies with a mission of advancing science and technology to augment the capability of member companies to develop transformational solutions that benefit patients, regulators, and the broader R&D community. (https://iqconsortium.org/) Please address any correspondence regarding this article to Wyatt Roth at roth_wyatt_james@lilly.com. the most effective mitigation strategies currently being used by tablet developers and manufacturers. The results provide a useful resource for novice practitioners who are still learning current industry practices as well as experi- enced personnel who wish to benchmark their practices against those of other companies. Moreover, the results have helped to identify the most important areas for future development in this field. Overwhelmingly, the respondents confirmed that there is a significant unmet need to establish predictive and robust models that can be used to identify sticking risks early in product development prior to transfer to the manufactur- ing site, when there are more prevention options available. Establishing such models would represent a step change in the industry's understanding of the underlying phenomenon of sticking from the current state, where most methods are reactive in nature rather than predic- tive. We hope is that publishing these survey results will promote additional awareness of this important topic, encourage further dialogue among industry and aca- demia, and potentially even initiate new research oppor- tunities to advance the science of tablet sticking. T&C References 1. Sayantan Chattoraj, Patrick Daugherity, Todd McDermott, Angela Olsofsky, Wyatt J. Roth, and Mike Tobyn, "Sticking and picking in pharmaceutical tablet compression: An IQ Consortium review," Journal of Pharmaceutical Sciences, Vol. 107, No. 9, pages 2,267-2,282. 2. K. Kakimi, T. Niwa, and K. Danjo, "Influence of compression pressure and velocity on tablet sticking," Chemical and Pharmaceutical Bulletin, Vol. 58, No. 12, pages 1,565-1,568. 3. Changquan Calvin Sun, "Dependence of ejection force on tableting speed—A compaction simulation study," Powder Technology, Vol. 279, pages 123-126. Omya Consumer Goods omya.com Innovative multifunctional mineral excipient · Highly porous and compactable carrier · Low friable fast disintegrating ODTs Calcium Carbonate & Tribasic Calcium Phosphate Omyapharm info.pharma@omya.com

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