Issue link: https://www.e-digitaleditions.com/i/1022930
Tablets & Capsules September 2018 21 the tooling manufacturing industry. This highlights the need for pharmaceutical companies to have a good work- ing relationship with their tooling supplier. Other process-related survey questions concerned the use of external lubrication and the impact of environmental conditions on sticking. As Figure 4 shows, four of the 12 respondents (33 percent) have successfully used external lubrication to mitigate a sticking problem. Additionally, half of the respondents (5/10) confirmed that environmen- tal conditions have impacted sticking, with the majority of those (4/5, or 80 percent) responding that moisture (rela- tive humidity) was more important than temperature. Conclusions These survey results provide valuable insights into the prevalence of sticking in the pharmaceutical industry and then the formulator/engineer will have little recourse but to work with the processing parameters and equipment available for that process. Table 3 lists the processing parameters and equipment changes respondents ranked as most effective for eliminating sticking. Interestingly, the top three perceived changes that help mitigate stick- ing all apply to direct compression, despite the fact that direct compression was ranked as the platform most prone to sticking. This finding may reflect the industry's desire to pursue direct-compression tableting when tech- nically feasible due to its simplicity and cost effectiveness compared to granulation-based tableting. It is also noteworthy that respondents ranked compres- sion tooling changes as the most effective process/equip- ment-related change, but the vast majority of the exper- tise in this area lies outside the pharmaceutical industry, in Figure 4 Impact of external lubrication and environmental conditions on sticking Has your company successfully used external lubrication to mitigate sticking? Have environmental conditions impacted sticking? 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