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Inhalation OCTOBER 2018 23 inhaler formulations. Dalby, R. et al. (Ed.), Respiratory Drug Delivery. Davies Healthcare International Pub- lishing, Tucson, AZ, USA (2018). 12. de Boer A, Hagedoorn P, Gjaltema D, Goede J, Fri- jlink H: Air classi er technology (ACT) in dry powder inhalation: Part 1. Introduction of a novel force distri- bution concept (FDC) explaining the performance of a basic air classi er on adhesive mixtures. International Journal of Pharmaceutics, 2003; 260: 187-200. 13. Begat P, Morton D, Staniforth J, Price R. e cohe- sive-adhesive balances in dry powder inhaler formula- tions I: Direct quanti cation by atomic force micros- copy. Pharm Research, 2004; 9: 1591-1597. 14. Price R, Young P, Edge S, Staniforth J: e in uence of relative humidity on particulate interactions in carri- er-based dry powder inhaler formulations. Interna- tional Journal of Pharmaceutics, 2004; 246: 47-59. 15. Kaialy W: A review of factors a ecting electrostatic charging of pharmaceuticals and adhesive mixtures for inhalation. International Journal of Pharmaceutics, 2016; 503: 262-276. 16. Harjunen P, Lankinen T, Salonen H, Lehto V, Järvinen K: E ects of carriers and storage of formula- tion on the lung deposition of a hydrophobic and hydrophilic drug from a DPI. International Journal of Pharmaceutics, 2003; 263:151-163. Nancy Rhein is a pharmacist and PhD student in the Department of Pharmaceutics and Biopharmaceutics, Kiel University. Gudrun Birk, PhD is the Laboratory Head, Controlled Release at Merck KGaA in Darmstadt, Ger- many. Regina Scherließ, PhD, Professor, is the Director of the Department of Pharmaceutics and Biopharmaceutics, Kiel University. Corresponding author: Nancy Rhein, Department of Pharmaceutics and Biopharmaceutics, Kiel University. Grasweg 9a, 24118 Kiel, Germany, Tel.: +49 431 880 13 45, nrhein@pharmazie.uni-kiel.de. Website: www.pharmazie.uni-kiel.de/technologie.