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BioPharm0619-SingleUseSystems

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18 BioPharm International eBook June 2019 www.biopharminternational.com Single-Use Systems Components The Importance of Single-Use Components for Bioprocessing Simple components help maintain physical integrity throughout a bioprocess setup, and single-use components play a role in ensuring a closed system for aseptic processing. S imple components such as tubing and gaskets are important for maintaining the physical integrity of a bioprocess setup. Single-use versions of these components offer convenience as well as play a role in maintaining aseptic processes, thus help- ing to ensure that the bioprocess setup is a closed system. Single-use innovations in bioprocess components have included enhancements in bioprocess bags—such as con- tact layers and bag functionalities—and newer inventive clamps, valves, and adapters (1). In a discussion with Ray Baldwin, business development manager for Biopure, a Watson-Marlow Fluid Technology Group (WMFTG) company, BioPharm International explores single-use com- ponents, such as tubing and gaskets, and the role such components play in bioprocessing. BENEFITS OF SINGLE-USE COMPONENTS BioPharm: What components in bioprocessing can easily benefit from being single-use? Baldwin: All components in bioprocessing could benefit from being single use, but it comes down to ensuring the practicality of the process for making the product while ensuring product security and operator safety at every stage of the process. As an example, the developments achieved in monoclonal antibody (mAb) titers when har- vesting product from bioreactors/fermenters have enabled nayladen - Stock.Adobe.com FELIZA MIRASOL

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