Issue link: https://www.e-digitaleditions.com/i/1199406
14 January 2020 Tablets & Capsules A Jon Carlisle Natoli Engineering A systematic approach to solving encapsulation problems caused by a sticky formulation capsule filling This article provides a best-practices approach to troubleshoot- ing capsule-filling problems when handling a sticky drug product formulation. sticky formulation is one of the most common causes of problems during capsule filling. A capsule filler requires tight tolerances between the machine's tooling components, including the dosing disks, tamping pins, and sealing plate, as well as between the capsules and the bores of the segments, which hold the capsules during filling. Friction between the formulation and these tool- ing components during high-speed operation can cause a sticky formulation to cake and glaze onto the tooling sur-