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35 April 2020 Tablets & Capsules C Benefits of multilayer and core tableting Jim Calvin and Ryan Keefer The Elizabeth Companies tableting This article provides a brief summary of the advantages of multilayer and core tableting techniques compared to tradi- tional, single-layer tableting. urrently, about two-thirds of all prescription drug prod- ucts are solid dosage forms. Many of these products pro- vide a combination of immediate and extended or delayed release of one or more active pharmaceutical ingredients (APIs). With the increased production of high-potency formulations and specialized solid dose applications in recent years, pharmaceutical companies are increasingly turning to innovative oral drug delivery systems such as multilayer and core tableting technologies. Multilayer tablets consist of one or more active matrix layers and one or more layers that act as barriers and reg- ulate API release. Core tableting (also called tablet-in-tab- let) technology consists of a premade, inner core tablet compressed within a surrounding granulation layer. Traditional core tableting used a pick-and-place, or vacuum type, method for placing the core tablets into the tablet press die cavity, but this was very unreliable and