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12 July 2020 Tablets & Capsules Smruti P. Chaudhari Yogesh Sadhale Metrics Contract Services Preventing powder binding during scale-up of a roller-compacted tablet formulation tableting R In this article, scientists at Metrics Contract Services developing a roller-compacted tablet formulation troubleshoot a powder- binding problem they encounter when scaling up the manufac- turing process from proof-of-concept scale to pilot scale. oller compaction is a method of dry granulation, in which a dry powder is densified into a solid mass, or compacted ribbon, which is then milled into granules. Roller compaction is often used in solid dosage manufac- turing because the resulting granules have better flow properties than the original powder for tableting or cap- sule filling. This article describes a study scientists con- ducted to resolve a powder-binding problem that devel-