Issue link: https://www.e-digitaleditions.com/i/1267517
24 July 2020 Tablets & Capsules Kerry Johanson Material Flow Solutions Mitigating segregation in batch feed systems content uniformity D Content uniformity is critical to the quality and performance of solid oral drug products. This article describes a study conducted to mitigate segregation of an example drug formula- tion during filling and discharge from a typical batch feeding process to ensure content uniformity of the final product. While the material and equipment discussed in this article are for a pharmaceutical application, the same principles apply to the nutraceutical, food, chemical, powdered metal, ceramic, and cosmetic industries. rug product developers carefully select excipients based on their function during the manufacturing pro- cess or in the final dosage form. Each ingredient must be present in the correct amount to ensure that the formula- tion adequately fills the tablet press die cavities or capsule filler tamping devices and does not stick to the tooling. Likewise, each finished tablet or capsule must contain the right mixture of ingredients to ensure that the product delivers the specified amount of active pharmaceutical ingredient (API) and dissolves at the appropriate rate and in the appropriate location within the patient's body.