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This section provides information that may be useful in research and development or manufacturing. Content is provided by the companies listed. No endorsement or preference is intended. 28 August 2020 Inhalation Special Section particle manufacturing This section of Inhalation provides information that may be useful in research and development or manufacturing. Content is provided by the organizations listed. No endorsement or preference is intended. Particle size reduction services Catalent is a global leader in particle size reduction services, delivering first-class micronization, milling and analytical services. Combined with quality and speed of response, Catalent offers expertise for both oral and inhaled dosage forms. Its full range of capabil- ities includes development through commercial scale, micronization (jet mill), mechanical milling (hammer mill, pin mill), cryogenic milling, controlled handling of potent and cytotoxic compounds and comprehen- sive supporting analytical services. Catalent US: + 1 888 SOLUTION (765-8846) www.catalent.com Active ingredients for nasal and oral inhalation Hovione has expertise in the science of drug substances for particle-based nasal and inhalation products. Crys- tallization, jet-milling and wet-milling spray-drying processes are developed by a quality by design (QbD) approach to deliver the physical, chemical and micro- biological critical quality attributes of the active phar- maceutical ingredient (API) and meet quality target product profiles for customers. Hovione offers several advanced particle characterization methodologies to provide in-depth knowledge of morphic and morpho- logic API properties. Hovione Portugal: + 351 21 982 9000 www.hovione.com Integrated DPI (dry powder inhaler) services Lonza Pharma & Biotech provides integrated DPI (dry powder inhaler) services to advance molecules, drawing on 25 years of experience in particle engineering, for- mulation design and encapsulation techniques. Our premier particle engineering services, utilizing both micronization and spray drying techniques, are tailored to your molecule, target product profile and delivery device. Dedicated DPI formulation and manufactur- ing teams ensure that development timelines are met, while minimizing program risk and complexity. Lonza Pharma & Biotech US: +1 201 316-9200 https://pharma.lonza.com Particle manufacture for inhaled delivery e manufacture of particles in a size range and form suitable for delivery to the lungs is one of the fundamen- tal building blocks in inhaled product development. Vectura has a wealth of experience in critical optimiza- tion of particle size and physical characteristics for active pharmaceutical ingredients (APIs) and excipients, to maximize delivery to the selected region of the respira- tory tract and create a high performing, stable product. Vectura has world-class capability in the development of a broad range of product types containing drug sub- stance "right sized" for inhalation by micronization, as well as substantial capability in "bottom up" particle engineering by spray drying to create sophisticated, sta- ble formulations that are especially suited to the delivery of biologic products by inhalation. Vectura UK: +44 1249 667700 www.vectura.com