Tablets & Capsules


Issue link:

Contents of this Issue


Page 10 of 67

Tablets & Capsules January/February 2021 9 Many technicians, operators, and process engineers know their capsule filling equipment inside and out, but problems occasionally arise that may require outside assistance. This article describes some common capsule filling problems, along with the corresponding correc- tive actions. While not all-inclusive, the issues covered here are the most prevalent problems our technical ser- vices teams are asked to address in the field. For this article, I'll assume that the formulation is compatible with the capsule, the capsule size is correct for the fill amount, the dosing-disk thickness is correct, and the formulation forms a suitable slug, depending on the capsule- filler type. Capsule shipping, handling, and storage Be sure to follow the capsule supplier's recom- mended shipping, handling, and storage conditions. Capsules may deform if exposed to high temperatures during shipping. Additionally, be sure to follow the supplier's guidelines when resealing cartons opened for inspection and sampling. Resealing the liner keeps the moisture barrier intact and prolongs the capsules' integrity. Once the capsule packaging is opened, limit- ing the amount of time the empty capsules spend in the open environment prior to filling is essential. Suppliers should provide recommended processing room condi- tions for the capsules they supply. It is important to note that the recommended stor- age and handling conditions may differ between capsule suppliers and between capsules made from gelatin and those made from hydroxypropyl meth- ylcellulose (HPMC). Gelatin capsules stored in low-humidity environments may lose moisture and become brittle. HPMC capsules, which have a lower moisture content than gelatin capsules, can absorb moisture if not held at the proper conditions during processing. Temperature excursions during transport, storage, and handling can lead to problems with both capsule separation and closing. Loose pieces A two-piece hard-shell capsule consists of a cap sec- tion and a body section, as shown in Figure 1. When the Once the capsule packaging is opened, limiting the amount of time the empty capsules spend in the open environment prior to filling is essential. This filter is just one of over 100,000 replacement filters and parts Donaldson has in-stock and ready to ship today. Not tomorrow. Today. Find this filter and thousands more at P190817-016-436 Ultra-Web ® fine fiber technology delivers longer filter life, cleaner air and greater cost savings. A proprietary substrate plus a fine fiber layer reduces pressure drop and increases airflow leading to longer filter life. © 2021 Donaldson Company, Inc. 800.365.1331

Articles in this issue

Links on this page

Archives of this issue

view archives of Tablets & Capsules - TC0121