Tablets Capsules

TC0121

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26 January/February 2021 Tablets & Capsules granulation Rahul Aware and Vasant Shetty ACG Using direct torque measurement to achieve precise endpoint determination in high-shear mixer granulation W This article discusses the advantages and disadvantages of different methods for determining the endpoint in a high-shear mixer granulation process and highlights the high-precision direct torque measurement technique. hile fluid-bed granulation is increasing in popularity, high-shear mixer (HSM) granulation remains the most preferred wet granulation method for tablet compres- sion and capsule filling formulations. This method is well established and achieves high-quality granules, but accurately identifying the granulation endpoint is crit- ical for the compression of good tablets and can be a major challenge.

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