Tablets & Capsules March/April 2021 27
Adherence: The Suppression of Bitter Taste in Edible Taste
Films." Advances in Pharmacological and Pharmaceutical Sciences,
2018. Vol. 2018, Article ID 8043837. Retrieved from https://
doi.org/10.1155/2018/8043837.
8. Julie Christensen. "How Long Do Vitamin Supple-
ments Last in the Bottle?" SFGATE. Retrieved from https://
healthyeating.sfgate.com/long-vitamin-supplements-last-
bottle- 11224.html.
Beverly Schad is a customer success innovation manager and
Jen Gornet is executive coordinator at Particle Dynamics (314
968 2376, www.particledynamics.com). Particle Dynamics is
a leading contract manufacturer for product development with
global pharma and consumer health companies. The company
provides a full range of solid dose applications and technologies,
including granulation, spray drying, lipid microencapsulation,
solid dose formulation with coating, tablet compression, encap-
sulation, and polysaccharide iron technologies.
able ibuprofen tablets for adults and children. The tablets
in both figures were manufactured using lipid microencap-
sulation technology (Micromask Ibuprofen 72%) to taste
mask the ibuprofen.
As the figures show, the products meet the USP mono-
graph release criteria for ibuprofen, with both the 50- and
100-milligram tablets consistently releasing 80 percent of
the ibuprofen within 10 minutes. Also, the taste tolerance of
the 50-milligram chewable ibuprofen tablet was acceptable
to children, validating that lipid microencapsulation works
well for taste masking unpleasant-tasting actives.
In the nutraceutical industry, lipid microencapsulation
has been used for several vitamin products to aid contract
manufacturers in product development. Examples of these
products are niacinamide, manganese sulfate, ferrous sulfate,
pyridoxine hydrochloride, thiamine mononitrate, ribofla-
vin, ferrous fumarate, magnesium oxide, ascorbic acid, zinc
oxide, and polysaccharide iron complex.
As these examples show, lipid microencapsulation can
provide solutions for formulating with challenging new active
ingredients. The congealing methodologies used to form
the lipid-active microparticles are established and proven
in the industry, and the number of approved products using
lipid microencapsulation is expected to continue to grow
in the next few years [2]. T&C
References
1. Globe Newswire. 2020. "The Microencapsulation mar-
ket is projected to grow at a CAGR of 12.9%." ReportLinker.
Retrieved from www.globenewswire.com/news-release/
2020/09/24/2098533/0/en/The-microencapsulation- market-
is-projected-to-grow-at-a-CAGR-of12-9.html.
2. Conrad Winters, Paula Cordiero, and Márcio Tem-
tem. "Spray congealing: applications in the Pharmaceutical
Industry." Chimica Oggi - Chemistry Today. 2013. Vol. 31, No.
5. Retrieved from www.teknoscienze.com/Contents/Riviste/
PDF/CO5_2013_RGB_71-75.pdf.
3. Catalent. 2020. "Boosting Bioavailability: How Com-
panies Are Using Advanced Technologies to Formulate
Complex Molecules." Retrieved from www.paperpicks.
com/boosting-bioavailability-how-companies-are-using-
advanced-technologies-to-formulate-complex- molecules/.
4. Takeshi Harayama and Howard Riezman. "Under-
standing the diversity of membrane lipid composition."
Nature Reviews Molecular Cell Biology. 2017. Vol. 19, pages 281-
296. Retrieved from https://doi.org/10.1038/nrm.2017.138.
5. David Chambers, Christopher Huang, and Gareth Mat-
thews. "The Cell Membrane." Chapter 4 in Basic Physiology
for Anaesthetists (pages 13-17). Cambridge University Press.
Retrieved from https://doi:10.1017/9781108565011.007.
6. Basavaraj K. Nanjwade, Didhija J. Patel, Ritesh A.
Udhani, and Fakirappa V. Manvi. "Functions of lipids
for enhancement of oral bioavailability of poorly water-
soluble drugs." Scientia pharmaceutica. 2011. Vol. 79, No. 4,
pages 705-727. Retrieved from https://doi.org/10.3797/
scipharm.1105-09.
7. Silvy Cherian, Brian Sang Lee, Robin M. Tucker, Kevin
Lee, and Gregory Smutzer. "Toward Improving Medication
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