Animal Health Solution - a Henry Schein Animal Health magazine for veterinary professionals
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Topical Parasiticide For Dogs and Cats BRIEF SUMMARY: See Package Insert for full Prescribing Information CAUTION: US Federal law restricts this drug to use by or on the order of a licensed veterinarian. INDICATIONS: Selarid is recommended for use in dogs six weeks of age or older and cats eight weeks of age and older for the following parasites and indications: Dogs: Selarid kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Selarid also is indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis. Cats: Selarid kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Selarid is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats. WARNINGS: Not for human use. Keep out of the reach of children. In humans, Selarid may be irritating to skin and eyes. Reactions such as hives, itching and skin redness have been reported in humans in rare instances. Individuals with known hypersensitivity to Selarid should use the product with caution or consult a health care professional. Selarid contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT). Wash hands after use and wash off any product in contact with the skin immediately with soap and water. If contact with eyes occurs, then flush eyes copiously with water. In case of ingestion by a human, contact a physician immediately. The safety data sheet (SDS) provides more detailed occupational safety information. For a copy of the SDS or to report adverse reactions attributable to exposure to this product, call 1-866-591-5777. Flammable – Keep away from heat, sparks, open flames or other sources of ignition. Do not use in sick, debilitated or underweight animals (see SAFETY). PRECAUTIONS: Prior to administration of Selarid, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Selarid is not effective against adult D. immitis and, while the number of circulating microfilariae may decrease following treatment, Selarid is not effective for microfilariae clearance. Hypersensitivity reactions have not been observed in dogs with patent heartworm infections administered three times the recommended dose of selamectin solution. Higher doses were not tested. ADVERSE REACTIONS: Pre-approval clinical trials: Following treatment with selamectin solution, transient localized alopecia with or without inflammation at or near the site of application was observed in approximately 1% of 691 treated cats. Other signs observed rarely (_<0.5% of 1743 treated cats and dogs) included vomiting, loose stool or diarrhea with or without blood, anorexia, lethargy, salivation, tachypnea, and muscle tremors. Post-approval experience: In addition to the aforementioned clinical signs that were reported in pre-approval clinical trials, there have been reports of pruritus, urticaria, erythema, ataxia, fever, and rare reports of death. There have also been rare reports of seizures in dogs (see WARNINGS). SAFETY: Selamectin solution has been tested safe in over 100 different pure and mixed breeds of healthy dogs and over 15 different pure and mixed breeds of healthy cats, including pregnant and lactating females, breeding males and females, puppies six weeks of age and older, kittens eight weeks of age and older, and avermectin-sensitive collies. A kitten, estimated to be 5–6 weeks old (0.3 kg), died 8½ hours after receiving a single treatment of selamectin solution at the recommended dosage. The kitten displayed clinical signs which included muscle spasms, salivation and neurological signs. The kitten was a stray with an unknown history and was malnourished and underweight (see WARNINGS). DOGS: In safety studies, selamectin solution was administered at 1, 3, 5, and 10 times the recommended dose to six-week-old puppies, and no adverse reactions were observed. The safety of selamectin solution administered orally also was tested in case of accidental oral ingestion. Oral administration of selamectin solution at the recommended topical dose in 5- to 8-month-old beagles did not cause any adverse reactions. In a pre-clinical study selamectin was dosed orally to ivermectin-sensitive collies. Oral administration of 2.5, 10, and 15 mg/kg in this dose escalating study did not cause any adverse reactions; however, eight hours after receiving 5 mg/kg orally, one avermectin-sensitive collie became ataxic for several hours, but did not show any other adverse reactions after receiving subsequent doses of 10 and 15 mg/kg orally. In a topical safety study conducted with avermectin-sensitive collies at 1, 3 and 5 times the recommended dose of selamectin solution, salivation was observed in all treatment groups, including the vehicle control. Selamectin solution also was administered at 3 times the recommended dose to heartworm infected dogs, and no adverse effects were observed. CATS: In safety studies, selamectin solution was applied at 1, 3, 5, and 10 times the recommended dose to six-week-old kittens. No adverse reactions were observed. The safety of selamectin solution administered orally also was tested in case of accidental oral ingestion. Oral administration of the recommended topical dose of selamectin solution to cats caused salivation and intermittent vomiting. Selamectin solution also was applied at 4 times the recommended dose to patent heartworm infected cats, and no adverse reactions were observed. In well-controlled clinical studies, selamectin solution was used safely in animals receiving other frequently used veterinary products such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, collars, shampoos and dips. STORAGE CONDITIONS: Store below 86∞F (30∞C). HOW SUPPLIED: Available in seven separate dose strengths for dogs and cats of different weights (see DOSAGE). Selarid for puppies and kittens is available in cartons containing 3 single dose applicators. Selarid for cats and dogs is available in cartons containing 6 single dose applicators. Approved by FDA under ANADA # 200-663 Manufactured by: Norbrook Laboratories Limited Newry, BT35 6PU, Co. Down, Northern Ireland Revised Dec 2019 402-2106 Selarid Brief Summary_7.625x10.125.indd 1 402-2106 Selarid Brief Summary_7.625x10.125.indd 1 3/2/21 4:47 PM 3/2/21 4:47 PM