Animal Health Solution - a Henry Schein Animal Health magazine for veterinary professionals
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IMOXI™ Topical Solution for Dogs and for Cats (imidacloprid + moxidectin) BRIEF SUMMARY: Before using IMOXI™ Topical Solution for Dogs (imidacloprid + moxidectin) or IMOXI™ Topical Solution for Cats (imidacloprid + moxidectin), please consult the product insert, a summary of which follows: CAUTION: Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. IMOXI™ Topical Solution for Dogs: INDICATIONS: IMOXI™ Topical Solution for Dogs is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. IMOXI™ Topical Solution for Dogs kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis). IMOXI™ Topical Solution for Dogs is indicated for the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var. canis. IMOXI™ Topical Solution for Dogs is also indicated for the treatment and control of the following intestinal parasites species: Hookworms (Ancylostoma caninum) and (Uncinaria stenocephala), Intestinal Stage: Adult, Immature Adult and Fourth Stage Larvae. Roundworms (Toxocara canis), Intestinal Stage: Adult and Fourth Stage Larvae. Roundworms (Toxascaris leonina), Intestinal Stage: Adult. Whipworms (Trichuris vulpis), Intestinal Stage: Adult. IMOXI TM Topical Solution for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. IMOXI TM Topical Solution for Cats kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. IMOXI TM Topical Solution for Cats is also indicated for the treatment and control of ear mite (Otodectes cynotis) infestations and the intestinal parasites species Hookworm (Ancylostoma tubaeforme), Intestinal Stage: Adult, Immature Adult and Fourth Stage Larvae. and Roundworm (Toxocara cati), Intestinal Stage: Adult and Fourth Stage Larvae. CONTRAINDICATIONS: Do not administer this product orally. (See WARNINGS) Do not use the Dog product (containing 2.5% moxidectin) on cats. WARNING DO NOT ADMINISTER THIS PRODUCT ORALLY For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Children should not come in contact with application sites for two (2) hours after application. (See Contraindications, Warnings, Human Warnings, and Adverse Reactions, for more information.) • • • WARNINGS: IMOXI™ Topical Solution for Dogs: For the first 30 minutes after application: Ensure that dogs cannot lick the product from application sites on themselves or other treated dogs, and separate treated dogs from one another and from other pets to reduce the risk of accidental ingestion. Ingestion of this product by dogs may cause serious adverse reactions including depression, salivation, dilated pupils, incoordination, panting, and generalized muscle tremors. In avermectin sensitive dogs, a the signs may be more severe and may include coma and death. b a Some dogs are more sensitive to avermectins due to a mutation in the MDR1 gene. Dogs with this mutation may develop signs of severe avermectin toxicity if they ingest this product. The most common breeds associated with this mutation include Collies and Collie crosses. b Although there is no specific antagonist for avermectin toxicity, even severely affected dogs have completely recovered from avermectin toxicity with intensive veterinary supportive care. IMOXI TM Topical Solution for Cats: Do not use on sick, debilitated, or underweight cats. Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight. HUMAN WARNINGS: Not for human use. Keep out of the reach of children. Dogs: Children should not come in contact with the application sites for two (2) hours after application. Cats: Children should not come into contact with the applicaiton site for 30 minutes after application. Causes eye irritation. Harmful if swallowed. Do not get in eyes or on clothing. Avoid contact with skin. Exposure to the product has been reported to cause headache; dizziness; and redness, burning, tingling, or numbness of the skin. Wash hands thoroughly with soap and warm water after handling. If contact with eyes occurs, hold eyelids open and flush with copious amounts of water for 15 minutes. If eye irritation develops or persists, contact a physician. If swallowed, call poison control center or physician immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by the poison control center or physician. People with known hypersensitivity to benzyl alcohol, imidacloprid or moxidectin should administer the product with caution. In case of allergic reaction, contact a physician. If contact with skin or clothing occurs, take off contaminated clothing. Wash skin immediately with plenty of soap and water. Call a poison control center or physician for treatment advice. The Safety Data Sheet (SDS) provides additional occupational safety information. To report suspected adverse drug events, for technical assistance or to obtain a copy of the SDS, contact Vetoquinol USA at 1-800-835-9496. PRECAUTIONS: Do not dispense dose applicator tubes without complete safety and administration information. Use with caution in sick, debilitated, or underweight animals. The safety of IMOXI™ Topical Solution for Dogs has not been established in breeding, pregnant, or lactating dogs. The safe use of IMOXI™ Topical Solution for Dogs has not been established in puppies and dogs less than 7 weeks of age or less than 3 lbs. body weight. Cats may experience hypersalivation, tremors, vomiting and decreased appetite if IMOXI TM Topical Solution for Cats is inadvertently administered orally or through grooming/licking of the application site. The safety of IMOXI TM Topical Solution for Cats has not been established in breeding, pregnant, or lactating cats. The effectiveness of IMOXI TM Topical Solution for Cats against heartworm infections (D. immitis) after bathing has not been evaluated in cats. Use of this product in geriatric patients with subclinical conditions has not been adequately studied. Several otherwise healthy, thin geriatric cats experienced prolonged lethargy and sleepiness after using imidacloprid and moxidectin topical solution. ADVERSE REACTIONS: Heartworm-Negative Dogs: The most common adverse reactions observed during field studies were pruritus, residue, medicinal odor, lethargy, inappetence and hyperactivity. Heartworm-Positive Dogs: The most common adverse reactions observed during field studies were cough, lethargy, vomiting, diarrhea (including hemorrhagic), and inappetence. ADVERSE REACTIONS - Cats: The most common adverse reactions observed during field studies were lethargy, behavioral changes, discomfort, hypersalivation, polydipsia and coughing and gagging. To report suspected adverse drug events, for technical assistance or to obtain a copy of the SDS, contact Vetoquinol USA at 1-800-835-9496. IMOXI™ Topical Solution for Dogs Approved by FDA under ANADA # 200-615 IMOXI TM Topical Solution for Cats Approved by FDA under ANADA # 200-638 Made in U.S.A. © 2019 Vetoquinol USA, Inc. Vetoquinol, the Vetoquinol logo, and IMOXI™ Topical Solution for Dogs and IMOXI™ Topical Solution for Cats are registered trademarks of Vetoquinol USA, Inc. R1 - 05/2020 C M Y CM MY CY CMY K Preferred by veterinary practices, PetFlex® cohesive bandages put your patients in good hands! PetFlex self-adhering elastic bandages are used on companion animals worldwide for affixing, splinting and light compression. • Features EasyTear technology for ease-of-use • Eliminates constriction over time for animal comfort • Provides reliability and quality - Made in USA Improving Animal Lives. Together. 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