1. O'Shaughnessy et al. Autologous protein solution prepared from the blood of osteoarthritic patients contains an enhanced profile of anti-inflammatory cytokines and anabolic growth factors. JOR 2014, 32, 1349-1355.
2. Bertone et al., Evaluation of a single intra-articular injection of autologous protein solution for treatment of osteoarthritis in horses. AJVR 2014, 75 (2), 141-151.
3. O'Shaughnessy et al., Blood-derived anti-inflammatory protein solution blocks the effect of IL-1β on human macrophages in vitro. Inflammation Research 2011, 60 (10), 929.
4. Woodell‐May et al., Autologous protein solution inhibits MMP‐13 production by IL‐1β and TNFα‐stimulated human articular chondrocytes. JOR 2011, 29 (9), 1320-1326.
5. King, W. et al., Human blood‐based anti‐inflammatory solution inhibits osteoarthritis progression in a meniscal‐tear rat study. JOR 2017, 35 (10), 2260-2268.
6. King, W.; Woodell-May, J., Comparison of the cellular and cytokine concentrations in the output of the autologous protein solution, orthokine, and onoccomed 2 device systems. Osteoarthritis and Cartilage 2014, 22,
S484.
References
THE PRO-STRIDE
DIFFERENCE
The Pro-Stride APS device processes the horses own blood at the point-of-
care by first isolating platelets and white blood cells in a small volume of
plasma then further concentrating these components with desiccating beads.
6
LEARN MORE
www.omveterinary.com/pro-stride
info@owlmanormedical.com
888.925.8269
Owl Manor Products are intended for the direct sale to and
use by licensed/practicing veterinarians.
There are several naturally occurring inhibitors (anti-inflammatory proteins)
of the pro-inflammatory cytokines IL-1 and TNF-alpha. These include IRAP / IL-1ra, sIL-1R, and sTNF-R.
All of these are highly concentrated within Pro-Stride APS.
Pro-Stride APS's output is neither PRP nor an autologous conditioned serum (ACS)
Pro-Stride's output does not require an incubation period
Pro-Stride's output is never frozen
Addressing Inflammatory Imbalance
White Blood Cells
Doc: M-315-P-Eq
Pro-Stride APS Processing
Step 1
Step 2
Relative Proportion of
Cells and Proteins in
Blood, L-PRP and Pro-
Stride APS
