Adverse Reaction Percent
Otitis externa and otorrhea 4.2
Increased serum alanine aminotransferase (ALT) 4.2
Increased serum alkaline phosphatase (ALP) 3.3
Pruritus, including pinnal 3.3
Tachycardia 3.3
Aggression 1.7
Dermatitis and eczema 1.7
Lymphopenia 1.7
Temporal muscle atrophy 1.7
Weight loss 1.7
Adipsia 0.8
Hypersalivation 0.8
Hypersensitivity reaction 0.8
Adverse Reaction Percent
Polydipsia 30.8
Polyuria 20.0
Tachypnea 16.7
Lethargy 11.7
Anorexia 10.0
Emesis 10.0
Muscle tremor/shaking 10.0
Hyperactivity 8.3
Anxiety 5.8
Desquamation/scaling/seborrhea 5.8
Diarrhea 5.0
Polyphagia/increased appetite 5.0
Alopecia and increased shedding 4.2
Table 1. Percentage of dogs experiencing adverse reactions
HO I
I
I
I O
H
NH
2
CO
2
Na
