Cannabis Patient Care - November 2021

Cannabis Patient Care November Issue

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15 research focus cannapatientcare.com october/november 2021 | cannabis patient care as antitumor agents," Oncotarget. DOI: 10.1016/j.jsps.2019.01.005. Retrieved from www.semanticscholar.org/paper/The-heterogeneity-and-complexity-of- Cannabis-as-Baram-Peled/ca3a543b372e5474439fbfc4bd5cbc4f41e904cf (2019). (6) J. Glogauer and J. Blay, "Cannabinoids, Their Cellular Receptors, and Effects on the Invasive Phenotype of Carcinoma and Metastasis" Cancer Reports. DOI: 10.1002/cnr2.1475. Retrieved from onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.1475 (2021). (7) Treatment Side Effects (2021, Mar 29). Breastcancer.org. Retrieved from www.breastcancer.org/treatment/side_effects. (8) J. Aviram, et al, "Short-Term Medical Cannabis Treatment Regimens Produced Beneficial Effects among Palliative Cancer Patients," Pharmaceuticals. DOI: 10.3390/ph13120435. Retrieved from www. researchgate.net/publication/346484148 (2020). (9) M. Weiss, et al "A survey of cannabis use for symptom palliation in breast cancer patients by age and stage," J. of Clinical Oncology. Retrieved from ascopubs.org/doi/abs/10.1200/JCO.2020.38.15_suppl.12108 (2020). (10) A.I. Fraguas-Sánchez, A. Fernández-Carballido, R. Simancas-Herbada, C. Martin- Sabroso, and A.I. Torres-Suárez, "CBD loaded microparticles as a potential formulation to improve paclitaxel and doxorubicin-based chemotherapy in breast cancer," International Journal of Pharmaceutics. DOI: 10.1016/j. ijpharm.2019.118916. Retrieved from pubmed.ncbi.nlm.nih.gov/31811927/ (2019). (11) M.M. Caffarel, C. Andradas, E. Pérez-Gómez, M. Guzmán, and C. Sánchez, "Cannabinoids: A new hope for breast cancer therapy?" Cancer Treatment Reviews. DOI: 10.1016/j.ctrv.2012.06.005. Retrieved from www.semanticscholar. org/paper/Cannabinoids%3A-a-new-hope-for-breast-cancer-therapy- Caffarel-Andradas/998e07defe9c75215c34acae8118718f0e5bf55f (2012). (12) M. Caffarel, et al, "D9-Tetrahydrocannabinol Inhibits Cell Cycle Progression in Human Breast Cancer Cells through Cdc2 Regulation," Cancer Research. DOI: 10.1158/0008-5472.CAN-05-4566. Retrieved from cancerres. aacrjournals.org/content/canres/66/13/6615.full.pdf (2006). (13) Breast Cancer Ploidy and Cell Proliferation. (2019, Sep 20) American Cancer Society. Retrieved from www.cancer.org/cancer/breast-cancer/ understanding-a-breast-cancer-diagnosis/ploidy-and-cell-proliferation.html. (14) L. Dobovišek, et al, "Cannabinoids and Hormone Receptor-Positive Breast Cancer Treatment," Cancers. DOI: 10.3390/cancers12030525. Retrieved from https://www. ncbi.nlm.nih.gov/pmc/articles/PMC7139952/pdf/cancers-12-00525.pdf (2020). (15) D. Ladin, et al, "Preclinical and Clinical Assessment of Cannabinoids as Anti-Cancer Agents," Frontiers in Pharmacology. DOI: 10.3389/ fphar.2016.00361. Retrieved from www.ncbi.nlm.nih.gov/pmc/ articles/PMC5054289/pdf/fphar-07-00361.pdf (2016). (16) M. Elbaz, et al, "Modulation of the Tumor Microenvironment and Inhibition of EGF/EGFR Pathway; Novel Anti-tumor Mechanisms Of Cannabidiol In Breast Cancer," Molecular Oncology. DOI: 10.1016/j. molonc.2014.12.010. Retrieved from www.meta.org/papers/modulation- of-the-tumor-microenvironment-and/25660577 (2015). (17) R. Murase, et al, "Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer," British J. of Pharmacology. DOI:10.1111/bph.12803. Retrieved from pubmed.ncbi.nlm.nih.gov/24910342/ (2014). (18) Apoptosis. (n.d.) National Cancer Institute. Retrieved from www.cancer.gov/publications/dictionaries/cancer-terms/def/apoptosis. (19) A. Tomko, et al, "Antitumor Activity of Abnormal Cannabidiol and Its Analog O-1602 in Taxol-Resistant Preclinical Models of Breast Cancer," Frontiers in Pharmacology. DOI: 10.3389/fphar.2019.01124. Retrieved from www.frontiersin.org/articles/10.3389/fphar.2019.01124/full (2019). (20) A. Sultan, M. Marie, and S. Sheweita, "Novel mechanism of cannabidiol- induced apoptosis in breast cancer cell lines," The Breast. DOI: 10.1016/j. breast.2018.06.009. Retrieved from pubmed.ncbi.nlm.nih.gov/30007266/ (2018). (21) A. Shrivastava, et al, "Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy," Mol. Cancer Ther. DOI: 10.1158/1535-7163.MCT-10- 1100. Retrieved from pubmed.ncbi.nlm.nih.gov/21566064/ (2011). (22) Angiogenesis. (n.d.) National Cancer Institute. Retrieved from www.cancer.gov/publications/dictionaries/cancer-terms/def/angiogenesis. (23) P. Picardi, E. Ciaglia, M. Proto, and S. Pisanti, "Anandamide inhibits breast tumor-induced angiogenesis," Transl. Med. UniSa. Retrieved from elea. unisa.it/jspui/bitstream/10556/1634/1/Picardi_Ciaglia_Proto_Pisanti_ Anandamide_inhibits_breast_tumor_induced_angiogenesis.pdf (2014). (24) N. Farsandaj, M. Ghahremani, and S. Ostad, "Role of cannabinoid and vanilloid receptors in invasion of human breast carcinoma cells," J. Environ. Pathol. Toxicol. Oncol. DOI: 10.1615/jenvironpatholtoxicoloncol.2013005859. Retrieved from pubmed.ncbi.nlm.nih.gov/23394450/ (2012). (25) P. Friedl and K. Wolf, "Tumour-cell invasion and migration: diversity and escape mechanisms," Nature Reviews Cancer. Retrieved from www.nature.com/articles/nrc1075/briefing/signup/ (2003). (26) S. Takeda, et al, "Cannabidiolic acid, a major cannabinoid in fiber- type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration," Toxicology Letters. DOI: 10.1016/j.toxlet.2012.08.029. Retrieved from pubmed.ncbi.nlm.nih.gov/22963825/ (2012). (27) S. Takeda, et al, "D9-Tetrahydrocannabinol enhances MCF-7 cell proliferation via cannabinoid receptor-independent signaling," Toxicology. DOI: 10.1016/j.tox.2007.12.019. Retrieved from www.sciencedirect. com/science/article/abs/pii/S0300483X07008566 (2008). (28) R. McKallip, M. Nagarkatti, and P. Nagarkatti, "∆-9-Tetrahydrocannabinol Enhances Breast Cancer Growth and Metastasis by Suppression of the Antitumor Immune Response," J. Immunol. DOI: 10.4049/jimmunol.174.6.3281. Retrieved from www.jimmunol.org/content/174/6/3281 (2005). (29) B. Dariš, M. Verboten, Z. Knez, and P. Ferk, "Cannabinoids in cancer treatment: Therapeutic potential and legislation," Bosnian J. of Basic Medical Sciences. DOI: 10.17305/bjbms.2018.3532. Retrieved from www.ncbi. nlm.nih.gov/pmc/articles/PMC6387667/pdf/BJBMS-19-14.pdf (2018). (30) T. Kisková, et al, Retrieved from Future Aspects for Cannabinoids in Breast Cancer Therapy. International J of Molecular Sciences. DOI: 10.3390/ijms20071673. Retrieved from www.ncbi.nlm.nih.gov/ pmc/articles/PMC6479799/pdf/ijms-20-01673.pdf (2019). About the author RUTH FISHER, PHD, is a systems design researcher and an- alyst. She analyzes markets to determine how environments shape outcomes. She is co-founder of CannDynamics, Inc., and author of The Medical Cannabis Primer and Winning the Hardware-Software Game: Using Game Theory to Optimize the Pace of New Technology Adoption. Dr. Fisher has worked in the technology and healthcare sectors on behalf of tech- nology companies, early-stage researchers, physicians, and technology start-ups.

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