Inhalation

INH0423

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Inhalation April 2023 17 6. Hede PD, Bach P, Jensen AD. Two-fluid spray atomisation and pneumatic nozzles for fluid bed coating/agglomeration purposes: A review. Chemi- cal Engineering Science. 2008;63(14):3821-3842. doi:10.1016/j.ces.2008.04.014. 7. Alhajj N, O'Reilly NJ, Cathcart H. Design- ing enhanced spray dried particles for inhala- tion: A review of the impact of excipients and processing parameters on particle properties. Pow- der Technology. 2021;384:313-331. doi:10.1016/j. powtec.2021.02.031. 8. Vehring R, Foss WR, Lechuga-Ballesteros D. Par- ticle formation in spray drying. Journal of Aero- sol Science. 2007;38(7):728-746. doi:10.1016/j. jaerosci.2007.04.005. 9. Tarara TE, Miller DP, Weers AE, et al. Formula- tion of dry powders for inhalation comprising high doses of a poorly soluble hydrophobic drug. Fron- tiers in Drug Delivery. 2022 Mar 15;2:862336. 10. Geller DE, Weers J, Heuerding S. Development of an inhaled dry-powder formulation of tobramy- cin using PulmoSphere™ technology. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2011;24(4):175-182. doi:10.1089/jamp.2010.0855. 11. United States Food and Drug Administration. Inactive ingredients in approved drug products. Data- base. https://www.fda.gov/media/164856/download. cial inhalation products manufactured using spray drying [3, 29], products in development that require high drug load, delivery of a biologic or rapid onset are increasingly using spray drying to manufacture a stable, highly respirable powder. References 1. Telko MJ, Hickey AJ. Dry powder inhaler formu- lation. Respiratory Care. 2005;50(9):1209-1227. 2. Vehring R. Pharmaceutical particle engineer- ing via spray drying. Pharmaceutical Research. 2007;25(5):999-1022. doi:10.1007/s11095-007- 9475-1. 3. Son YJ, Miller DP, Weers JG. Optimizing spray-dried porous particles for high dose deliv- ery with a portable dry powder inhaler. Pharma- ceutics. 2021;13(9):1528. doi:10.3390/pharma ceutics13091528. 4. Chow AHL, Tong HHY, Chattopadhyay P, et al. Particle engineering for pulmonary drug deliv- ery. Pharmaceutical Research. 2007;24(3):411-437. doi:10.1007/s11095-006-9174-3. 5. Mosén K, Bäckström K, alberg K, et al. Par- ticle formation and capture during spray drying of inhalable particles. Pharmaceutical Development and Technology. 2004;9(4):409-417. doi:10.1081/ pdt-200035795.

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