Animal Health Solution - a Henry Schein Animal Health magazine for veterinary professionals
Issue link: https://www.e-digitaleditions.com/i/1501962
Compounding can be a money-saver, but with equine protozoal myeloencephalitis (EPM), it's a risky compromise. ReBalance ® gives you confidence. ReBalance ® Antiprotozoal Oral Suspension (sulfadiazine and pyrimethamine) is the only FDA-approved combination of sulfadiazine and pyrimethamine, offering a safe and effective treatment for horses with EPM caused by Sarcocystis neurona. Choose confidence over compromise. Choose ReBalance. PRNPharmacal.com PRN® and ReBalance® are registered trademarks of Pegasus Laboratories, Inc. 4/23 644195 EPM is too serious for this. Important Safety Information For use in horses only. Do not use in horses intended for human consumption. Not for human use. Keep out of the reach of children. Prior to treatment with ReBalance Antiprotozoal Oral Suspension, EPM should be distinguished from other diseases that may cause ataxia in horses. Injuries or lameness may also complicate the evaluation of an animal with EPM. In most instances, ataxia due to EPM is asymmetrical and affects the front and/or the hind limbs. Treatment may cause generalized bone marrow suppression, anemia, leukopenia, neutropenia, and thrombocytopenia. A complete blood count (CBC) should be performed monthly to monitor horses for development of these conditions. The administration of the drug may need to be discontinued and/or treatments for bone marrow suppression initiated. Other, less frequent side effects included decreased appetite, loose stools, and mild colic. In most cases, the gastrointestinal signs were self-limiting and did not require discontinuation of treatment. Worsened neurologic deficits (treatment crisis) may be observed during a period beginning with the first few days of treatment with ReBalance and ranging out to 5 weeks. This neurologic deficit exacerbation may be the result of an inflammatory reaction to the dying parasites in the CNS tissue. The safe use of ReBalance Antiprotozoal Oral Suspension in horses used for breeding purposes, during pregnancy, or in lactating mares has not been evaluated. The safety of ReBalance with concomitant therapies in horses has not been evaluated. ReBalance is not for use in horses with known hypersensitivity to sulfonamide drugs or pyrimethamine. Refer to the prescribing information for complete details or visit prnpharmacal.com/rebalance. 1 Animal Health Pharmaceuticals. Freedom of information summary, NADA 141–240. REBALANCE Antiprotozoal Oral Suspension (sulfadiazine and pyrimethamine) "for the treatment of horses with equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona." Animal Health Pharmaceuticals, LLC, St. Joseph, MO; 2004. 2 Johnson AL. Evidence-Based Review of Diagnosis and Treatment of Sarcocystis neurona Infection (Equine Protozoal Myeloencephalitis), in Proceedings. 55th Annual American Association of Equine Practitioners Convention 2009; 172-176. ©2015 Pegasus Laboratories, Inc. PRN® and ReBalance® are all trademarks of Pegasus Laboratories, Inc. REB-8/15-02