Issue link: https://www.e-digitaleditions.com/i/1509606
This section provides information that may be useful in research and development or manufacturing. Content is provided by the companies listed. No endorsement or preference is intended. ISSUE FOCUS Devices This section of Inhalation provides information that may be useful in research and development or manufacturing. Content is provided by the companies listed. No product endorsement or preference is intended. Inhalation OctOber 2023 23 A patient exhalation simulator (PES) Evaluating the performance of drug/device com- binations under real-world conditions is becoming increasingly important. In our continuing efforts to deliver innovative testing solutions to those devel- oping inhaled drug products, we are pleased to add the Patient Exhalation Simulator (PES) to our com- prehensive portfolio. Exhalation into the inhaler mouthpiece prior to inhalation is a commonly reported error in patient technique, especially with dry powder inhalers (DPIs). e PES can enable ana- lysts to accurately replicate this effect, enabling the impact of this misuse condition and device robust- ness to be assessed. Copley Scientific UK: +44 1159 616229 sales@copleyscientific.co.uk www.copleyscientific.com A new pMDI ferrule design Today's pressurized metered dose inhalers (pMDIs) are a marvel of modern technology. Inhalers depend upon gas pressure to create the proper medica- tion droplet size and propel it into the respiratory tract. To ensure this process, a water bath inspection verifies container closure integrity against compo- nent defects and manufacturing issues. MKON's patent-pending ferrule design can eliminate trapped propellant during water bath inspection, thereby minimizing false negative results. Click to see a video depicting and comparing gas leakage between cur- rent and MKON ferrules. MKON US: +1 908 240-4567 info@mkonllc.com www.mkonllc.com Plasma process for treating MDI canisters H&T Presspart offers a unique plasma process—man- ufactured under license from Portal Medical Ltd—for treating the internal surfaces of metered dose inhaler (MDI) canisters, which can help ensure the active drug content does not stick to the canister wall. is fluorocarbon polymerization (FCP) plasma treatment process can improve the surface energy performance of an MDI canister, which can enhance drug stability in formulations where interactions with the alumin- ium substrate can lead to product degradation and reduced shelf life. H&T Presspart UK: +44 1254 582233 blackburn@presspart.com www.presspart.com