Animal Health Solution - a Covetrus magazine for veterinary professionals
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17 Q4 2023 | Animal Health Solutions What's new in ocular research? How does the increased residence time of Oculenis on the ocular surface and its unique crosslinked HA matrix impact healing? Sentrx has completed a proof-of- concept study 3 comparing healing rates of hyaluronic acid hydrogel and amniotic drops in rats. This proof-of-concept study was also presented at the 2022 ACVO Scientific Conference. In this study, the cornea was considered healed when there was no fluorescein staining on the corneal surface. This proof-of-concept study showed a greater than 50% increase in healing rates of corneal injuries treated with crosslinked HA, BioHAnce, compared to saline controls. It is also worth noting that measurements for the study were formally stopped at 72 hours; in some control groups it took over 100 hours for complete reepithelization. Thus, if the study was not stopped at 72 hours an even greater difference in healing rates would have been seen. Crosslinked HA also showed reduced healing time in comparison to amniotic eye drops. This result warrants further study into the comparative efficacy of hydrogels in corneal healing time in dogs and will be further investigated. The histopathology reported here indicates that not only is healing faster with the matrix provided by crosslinked HA, but it also appears healthier and closer to normal uninjured morphologies as seen by the images below. While this research is promising, Oculenis and crosslinked HA is not a one- for-one substitute of serum. Serum contains factors that can neutralize collagenase activity. Collagenases are enzymes that break the peptide bonds in collagen. They assist in destroying extracellular structures in the pathogenesis of bacteria. Thus in complex cases of infected ulcers serum still may be required. However, with its unique crosslinked HA matrix that delivers extended residence time and support for accelerated healing, Oculenis and crosslinked HA should also be considered. XHA Treated (Oculenis) Control T=0 T=12 T=24 T=36 T=48 T=72 Abstracts: 53rd Annual Meeting of the American College of Veterinary Ophthalmologists, Palm Springs, CA, USA October 26–29, 2022. Vet Ophthalmol, 26: e1-e22. https://doi.org/10.1111/vop.13045 1. Davis RL, Latham EA, Townsend WM. Clinical Outcomes of Infected Corneal Ulcers in Dogs Treated with and Without Topical Serum. 2. Kubai MA, Allbaugh RA, Stinman CC, Kenne DE, Moniot JM, Baum DH, Roy MM, Sebbag L. Canine and Equine Serum/Plasma Modulate the Effect of Topical Antibiotics Against Common Bacterial Pathogens in Dogs with Infectious Keratitis. 3. Montiani-Ferreira F, Atzet SK, Fankhauser AD, Behan EK, Haeussler DJ. Fluorometric Evaluation of Crosslinked Vs Linear Hyaluronic Acid Eye Drops. To learn more about the studies please visit sentrxanimalcare.com/ learnmore