Issue link: https://www.e-digitaleditions.com/i/1521797
Inhalation June 2024 19 43. Z. Wang, H. Wang and R. Vehring, Leucine enhances the dispersibility of trehalose- containing spray-dried powders on exposure to a high- humidity environment, Int J Pharm, vol. 601, p. 120561, 2021, doi: 10.1016/j.ijpharm.2021.120561. 44. A. García-Arieta, S. Torrado-Santiago, L. Goya and J. J. Torrado, Spray-dried powders as nasal absorption enhancers of cyanocobalamin, Biol Pharm Bull, vol. 24, no. 12, pp. 1411-1416, 2001, doi: 10.1248/bpb.24.1411. 45. Y. Huh, H. J. Cho, I. S. Yoon, M. K. Choi, J. S. Kim, E. Oh, S. J. Chung, C. K. Shim and D. D. Kim, Preparation and evaluation of spray-dried hyaluronic acid microspheres for intranasal delivery of fexofen- adine hydrochloride, Eur J Pharma Sci, vol. 40, no. 1, pp. 9-15, 2010, doi: 10.1016/j.ejps.2010.02.002. 46. A. Pomázi, R. Ambrus, P. Sipos and P. Szabó- Révész, Analysis of co-spray-dried meloxicam– mannitol systems containing crystalline microcom- posites, J Pharm Biomed Anal, vol. 56, no. 2, pp. 183-190, 2011, doi: 10.1016/j.jpba.2011.05.008. William Wei Lim Chin, PhD, is the Manager of Global Scientific Affairs at Catalent Pharma Solutions, Gam- melsbacher Str. 2, 69412 Eberbach, Germany. Michael A. Sandoval, MSc, is a Graduate Student in the Divi- sion of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, e University of Texas at Aus- tin, Austin, TX 78712, US. Alan B. Watts, PhD, is the Director of Innovation and Partnerships for Orally Inhaled Products at Catalent Pharma Solutions, 14 School House Road, Somerset, NJ 08873, US. Corre- sponding author: Alan B. Watts, PhD, alan.watts1@ catalent.com, www.catalent.com. 33. F. W. H. M. Merkus, J. C. Verhoef, E. Mart- tin, S. G. Romeijn, P. H. M. van der Kuy, W. A. J. J. Hermens and N. G. M. Schipper, Cyclodex- trins in nasal drug delivery, Adv Drug Deliv Rev, vol. 36, no. 1, pp. 41-57, 1999, doi: 10.1016/ S0169-409X(98)00054-4. 34. A. E. Pontiroli, Intranasal glucagon: A promis- ing approach for treatment of severe hypoglycemia, J Diabetes Sci Technol, vol. 9, no. 1, pp. 38-43, Nov. 2014, doi: 10.1177/1932296814557518. 35. J. M. Figueroa, M .E. Lombardo, A. Dogliotti, L. P. Flynn, R. Giugliano, G. Simonelli, R. Valentini, A. Ramos, P. Romano, M. Marcote, A. Michelin, A. Salvado, E. Sykora, C. Kniz, M. Kobelinsky, D.M. Salzberg, D. Jerusalinsky and O. Uchitel, Efficacy of a nasal spray containing iota-carrageenan in the post- exposure prophylaxis of COVID-19 in hospital per- sonnel dedicated to patients care with COVID-19 disease, Int J Gen Med, vol. 14, pp. 6277-6286, Oct. 1 2021, doi: 10.2147/IJGM.S328486. 36. L. Casettari and L. Illum, Chitosan in nasal deliv- ery systems for therapeutic drugs, JCR, vol. 190, pp. 189-200, 2014, doi: 10.1016/j.jconrel.2014.05.003. 37. L. Illum, I. Jabbal-Gill, M. Hinchcliffe, A. N. Fisher, and S. S. Davis, Chitosan as a novel nasal delivery system for vaccines, Adv Drug Deliv Rev, vol. 51, no. 1, pp. 81-96, 2001, doi: 10.1016/ S0169-409X(01)00171-5. 38. R. Popescu, M. V. Ghica, C.-E. Dinu-Pîrvu, V. Anuța, D. Lupuliasa and L. Popa, New opportunity to formulate intranasal vaccines and drug delivery systems based on chitosan, Int J Mol Sci, vol. 21, no. 14, 2020, doi: 10.3390/ijms21145016. 39. N. Hussein, H. Omer, A. Ismael, M. Albed Alhnan, A. Elhissi and W. Ahmed, Spray-dried algi- nate microparticles for potential intranasal delivery of ropinirole hydrochloride: Development, charac- terization and histopathological evaluation, Pharm Dev Technol, vol. 25, no. 3, pp. 290-299, Mar. 2020, doi: 10.1080/10837450.2019.1567762. 40. M. Tafaghodi and S. Rastegar, Preparation and in vivo study of dry powder microspheres for nasal immunization, J Drug Target, vol. 18, no. 3, pp. 235- 242, Apr. 2010, doi: 10.3109/10611860903434035. 41. R. J. Garmise, H. F. Staats and A. J. Hickey, Novel dry powder preparations of whole inactivated influenza virus for nasal vaccination, AAPS Pharm- SciTech, vol. 8, no. 4, p. 81, 2007, doi: 10.1208/ pt0804081. 42. R.J. Garmise, K. Mar, T. M. Crowder, C. R. Hwang, M. Ferriter, J. Huang, J. A. Mikszta, V. J. Sullivan and A. J. Hickey, Formulation of a dry pow- der influenza vaccine for nasal delivery, AAPS Pharm- SciTech, vol. 7, no. 1, p. 19, 2017, doi: 10.1208/ pt070119.