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22 Pharmaceutical Technology ® Trends in Formulation eBook September 2024 PharmTech.com VK STUDIO - STOCK.ADOBE.COM O ral drug delivery has been and remains a fundamental approach in pharmaceutical as well as nutraceutical administration. It continues to evolve to ensure the successful integration of cutting-edge innovations and to meet the challenges posed by emerging technologies. Renowned for its user-friendliness, manufacturing convenience, and therapeutic advantages, oral deliv- ery represents the gold standard for administering therapeutic agents. It enables the efficient delivery of a diverse array of therapeutics, spanning from small molecular drugs to proteins, peptides, nucleic acids, and even bio-actives. A pivotal advancement in this field, multi-particu- late systems are emerging as a well-established meth- odology across various industries. This system has not only amplified scope to modify the physicochemical properties but also redefined the paradigm of release modulation for active compounds. Serving as a versa- tile platform for formulating both pharmaceuticals and nutraceutical supplements, the multi-particulate system boasts a plethora of advantages over traditional dosage forms. This includes particle fractionation to di- vide active constituents into minute particles, yielding benefits such as precise dosing, heightened bioavail- ability, and enhanced stability. The approach offers exceptional flexibility in modulating release kinetics, enabling tailored delivery profiles to improve thera- peutic efficacy and patient adherence. Among multi-par ticulate formulations, pellets stand as the foremost dosage form in the market due to their versatility across various therapeutic ranges. Their adaptability across capsules, tablets, and sachet forms offers distinct advantages that cater to diverse patient preferences and therapeutic requirements in both the pharmaceutical and nutraceutical sectors. Pelletization, a popular oral drug delivery method in pharmaceuticals and nutraceuticals, offers numerous benefits. This article delves into the critical parameters for formulation development and technological consideration in pelletization, elucidating its significance in advancing pharmaceutical solutions. Pelletization: Revolutionizing Drug Formulation and Delivery Surya Singh, Jnanadeva Bhat, and Manali Dalvi