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Inhalation February 2025 29 9. V'Kovski, P., et al., Coronavirus biology and rep- lication: Implications for SARS-CoV-2. Nat Rev Microbiol, 2021. 19(3): p. 155-170. 10. e Nobel Prize in Physiology or Medicine 2006. e Nobel Prize in Physiology or Medicine 2006 was awarded jointly to Andrew Z. Fire and Craig C. Mello "for their discovery of RNA interference - gene silencing by double-stranded RNA." 2006 28.05.2022; https://www.nobelprize.org/prizes/ medicine/2006/summary/. 11. Narasipura, E.A., et al., Ongoing clinical trials of nonviral siRNA therapeutics. Bioconjug Chem, 2023. 34(7): p. 1177-1197. 12. e Nobel Prize in Physiology or Medicine 2023. e Nobel Prize in Physiology or Medicine 2023 was awarded jointly to Katalin Karikó and Drew Weissman "for their discoveries concerning nucle- oside base modifications that enabled the develop- ment of effective mRNA vaccines against COVID- 19." 2023 25.07.2024; https://www.nobelprize.org/ prizes/medicine/2023/summary/. 13. e Nobel Prize in Physiology or Medicine 1962. e Nobel Prize in Physiology or Medicine 1962 was awarded jointly to Francis Harry Comp- ton Crick, James Dewey Watson and Maurice Hugh Frederick Wilkins "for their discoveries concerning the molecular structure of nucleic acids and its sig- nificance for information transfer in living mate- rial." 1962 25.07.2024; https://www.nobelprize.org/ prizes/medicine/1962/summary/. 14. Rana, T.M., Illuminating the silence: Under- standing the structure and function of small RNAs. Nat Rev Mol Cell Biol, 2007. 8(1): p. 23-36. 15. Hutvagner, G., et al., A microRNA in a multiple- turnover RNAi enzyme complex. Science, 2002. 297: p. 2056-2060. 16. Baldassi, D., et al., Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER poly- plexes. J Control Release, 2022. 345: p. 661-674. 17. Wang, D., et al., Adeno-associated virus vector as a platform for gene therapy delivery. Nat Rev Drug Discov, 2019. 18(5): p. 358-378. 18. omas, C.E., et al., Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet, 2003. 4(5): p. 346-358. 19. Kazemian, P., et al., Lipid-nanoparticle-based delivery of CRISPR/Cas9 genome-editing compo- nents. Mol Pharm, 2022. 19(6). 20. Jiang, A.Y., et al., Combinatorial development of nebulized mRNA delivery formulations for the lungs. Nat Nanotechnol, 2024. 19(3): p. 364-375. 21. Zhang, H., et al., Aerosolizable lipid nanopar- ticles for pulmonary delivery of mRNA through design of experiments. Pharma, 2020. 12(11). www.inhalationmag.com Designed to provide educational content, the Inhalation 1-2-3 e-newsletter includes a supplier's perspective on industry issues, highlights technical articles from the magazine and previews industry conferences. Please watch for it in your inbox every other month. Sign up now by emailing your name, company name and email address to subscriptions@inhalationmag.com.