Animal Health Solutions

38 Covetrus | 877-999-2838 | covetrus.com The Science of Resolving Joint Inflammation in Pet Osteoarthritis Osteoarthritis continues to be one of the most common and challenging conditions in veterinary practice. The primary cause of this degenerative disease is unresolved joint inflammation, which can lead to cartilage breakdown, pain, and reduced mobility. While the signs of early inflammation might go unnoticed, the long-term impact on a pet's quality of life is undeniable. Advancements in resolution pharmacology now offer veterinarians new tools to help resolve inflammation and promote healing before irreversible joint damage occurs. Proactive Strategies for Managing Canine Osteoarthritis Early intervention is critical in managing osteoarthritis effectively, as the disease is driven by uncontrolled inflammation that gradually erodes cartilage. A proactive, multi-modal approach can mitigate inflammation and protect joint cartilage, even before clinical signs of joint damage become evident. Veterinarians should consider incorporating the following into their osteoarthritis management plans: Pro-Resolving Therapy Pro-resolving mediators, derived from omega-3 fatty acids, actively resolve inflammation rather than merely suppressing it. Unlike standard omega-3s, these mediators bypass the need for enzymatic conversion, which is often hindered by the effects of aging or the use of NSAIDs and corticosteroids. Cartilage Protection Polysulfated glycosaminoglycan (PSGAG) injections are a key tool for protecting joint cartilage. These injections not only inhibit cartilage breakdown but also integrate into both healthy and damaged cartilage to help maintain joint structure and function. Transforming the Way We Approach Joint Health Integrating pro-resolving therapies into osteoarthritis management plans enables a shift in focus from merely masking symptoms to actively resolving inflammation and supporting long-term joint health. With the right combination of strategies and products, veterinarians can pave the way for better outcomes and improved quality of life for their patients. One example of a clinically proven joint supplement designed to aid in the resolution of inflammation is Antinol ® Plus 1,2,3 . With its proprietary blend of green-lipped mussel oil and Antarctic krill oil, it supports tissue repair while inhibiting key inflammatory markers. With over 40 years of research and multiple clinical trials demonstrating efficacy, Antinol ® Plus is a vital tool in any veterinarian's arsenal for managing osteoarthritis in pets. 1. Treschow AP, Hodges LD, Wright PFA, Wynne PM, Kalafatis N, Macrides TA. Novel anti-inflammatory ‐-3 PUFAs from the New Zealand green-lipped mussel, Perna canaliculus. Comp Biochem Physiol B Biochem Mol Biol. 2007;147(4):645-656. 2. 1McPhee S, Hodges LD, Wright PFA, et al. Anti-cyclooxygenase effects of lipid extracts from the New Zealand green-lipped mussel, Perna canaliculus. Comp Biochem Physiol B Biochem Mol Biol. 2007;146(3):346-356. 3. Lipidomic Profiling of PCSO-524 and EAB-277. In. Proprietary Data on File2020.

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