Animal Health Solution - a Covetrus magazine for veterinary professionals
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All trademarks are the property of their respective owners. Copyright © 2024 Merck & Co., Inc., Rahway, NJ, USA and its affiliates. All rights reserved. US-NOV-241100008 698921 References: 1. Singler E. Update: AAHA guidelines designate Leptospirosis vaccine as core. American Animal Hospital Association. October 29, 2024. Accessed November 19, 2024. https://www.aaha.org/newstat/publications/leptospirosis-vaccination-recommended-to-be-core-for-most-dogs/ 2. LaFleur RL, Dant JC, Wasmoen TL. Prevention of disease and mortality in vaccinated dogs following experimental challenge with virulent Leptospira. J Vet Int Med. 2011;25:747. 3. LaFleur RL, Dant JC, Tubbs AL, Jayappa H, Sutton D, Tarpey I. Prevention of leptospiremia and leptospiruria following vaccination with a DAPPv + 4-way Leptospira combination vaccine. Presented at: Proceedings of the ISCAID Symposium; October 16-19, 2016; Bristol, UK. 4. Data on file. Merck Animal Health. 5. Nobivac ® Lepto 4 . Product label. Merck Animal Health; 2018. 6. Nobivac EDGE ® Lepto 4 . Product label. Merck Animal Health; 2019. 7. ULTRA Duramune ® 4L. Product label. Elanco US Inc.; 2017. 8. Vanguard ® L4. Product label. Zoetis, Inc; 2018. 9. RECOMBITEK ® 4 Lepto. Product label. Merial; 2011. 10. LeptoVax™ 4. Product label. Elanco; 2017. 11. LaFleur RL, Dant JC, Tarpey I. One year duration of immunity of a multivalent Leptospira bacterin using a Leptospira challenge model. Presented at: The ISCAID Symposium; September 30-October 3, 2018; Portland, OR. Protection unites us. Customer Service: 1-800-521-5767 (Monday–Friday, 9:00am–6:00pm EST) Technical Services: 1-800-224-5318 (Monday–Friday, 9:00am–6:00pm EST) To learn more, contact your Merck Animal Health sales representative or your distributor representative. VACCINATE WITH PEACE OF MIND. VACCINATE WITH NOBIVAC ® LEPTO 4 . *Formerly ULTRA Duramune ® 4L † Formerly LeptoVax ™ 4 Shown to be effective against leptospirosis Shown to be 100% effective against leptospiruria caused by all 4 serovars 3 Leptospira canicola L grippotyphosa L icterohaemorrhagiae L pomona Effective against mortality caused by... Leptospira serovars One-year protection study 11 Study includes 4 serovars Nobivac ® Lepto 4 5 VANGUARD ® L4 8 RECOMBITEK ® 4 Lepto 9 TruCan TM L4 10† TruCan™ Ultra L4 7 * Nobivac EDGE ® Lepto 4 6 VacciPure ™ filtration technology Filtration membrane AFTER FILTRATION BEFORE FILTRATION Purified solution Extraneous proteins Applied pressure Filtration membrane Fewer total proteins means a more purified final product, which may reduce unwanted immune system responses, such as vaccine reactions. 4 Dogs' lives are unique. Their protection should be, too.

