Inhalation

INH0226

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34 February 2026 Inhalation sulfate Spiros inhaler and albuterol metered-dose inhaler in asthma. Chest. 1999;115(2):329-335. doi:10.1378/chest.115.2.329 15. de Boer AH, Hagedoorn P, Hoppentocht M, Buttini F, Grasmeijer F, Frijlink HW. Dry powder inhalation: Past, present and future. Expert Opinion of Drug Delivery. 2017;14:499-512. https://www. tandfonline.com/doi/10.1080/17425247.2016.122 4846?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref. org&rfr_dat=cr_pub%20%200pubmed 16. Zhu L, Khandeshi A, Xu MA, Bai Y, Kedia V, et al. Evaluation of a novel pediatric asthma inhalation drug delivery device: A focus on patient accessibility, ease of use, dosage feedback, and future directions. Journal of Asthma. 2025;62(3):404-409. doi:10.108 0/02770903.2024.2404991 17. Hamilton M, Leggett R, Pang C, Charles S, Gillett B, Prime D. In vitro dosing performance of the Ellipta ® Dry Powder Inhaler using asthma and COPD patient inhalation profiles replicated with the Electronic Lung (eLungTM). Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2015;28(6):498-506. doi:10.1089/jamp.2015.1225 18. Jones TL, Neville DM, Chauhan AJ. e Ellipta ® in asthma and chronic obstructive pulmonary disease: Device characteristics and patient acceptability. er- apeutic Delivery. 2018;9(3):169-176. doi:10.4155/ tde-2017-0103 19. Dal Negro RW. Dry powder inhalers and the right things to remember: A concept review. Multi- disciplinary Respiratory Medicine. 2015;10(1):13. doi:10.1186/s40248-015-0012-5 Lily Zhu, BS, Medical Student, 1 corresponding author, lzhu31@jhmi.edu Punthitra Arpornsuksant, MD, Anesthesiology Resident 1 Maxwell A. Xu, MS, PhD Candidate 1 Isaree Pitaktong, BS, MD–PhD Student 1 Varun Kedia, MSE, Regulatory Affairs Specialist 1 Syed Yusuf Ali, MS, PhD Candidate 1 George L. Coles, MS, Principal Staff Engineer 2 Yunong Bai, BS, Medical Student 1 Damali Egyen-Davis, BS, MBA Candidate 1 Mandeep Jassal, MD MPH, Global Clinical Program Lead 3 Carlton K. K. Lee, PharmD, MPH, Clinical Phar- macy Specialist 4 1 Department of Biomedical Engineering, Johns Hop- kins University, Baltimore, Maryland, US 2 e Johns Hopkins University Applied Physics Labo- ratory, Laurel, Maryland, US 3 Department of Pediatric Pulmonology, Johns Hopkins University, Baltimore, MD, US 4 Department of Pharmacy, e Johns Hopkins Hospi- tal and Department of Pediatrics, Johns Hopkins Uni- versity, Baltimore, MD, US 4. Vincken W, Levy ML, Scullion J, Usmani OS, Dekhuijzen PNR, Corrigan CJ. Spacer devices for inhaled therapy: Why use them, and how? ERJ Open Research. 2018;4(2): 00065. doi:10.1183/23120541.00065-2018 5. Allergy & Asthma Network. How to use a dry powder inhaler. https://allergyasthmanet work.org/what-is-asthma/how-is-asthma-treated/ how-to-use-a-dry-powder-inhaler/ 6. Kawamatawong T, Khiawwan S, Pornsuriyasak P. Peak inspiratory flow rate measurement by using In-Check DIAL for the different inhaler devices in elderly with obstructive airway diseases. Journal of Asthma and Allergy. 2017;10:17-21. doi:10.2147/ JAA.S127580 7. Grant AC, Walker R, Hamilton M, Garrill K. e Ellipta ® Dry Powder Inhaler: Design, function- ality, in vitro dosing performance and critical task compliance by patients and caregivers. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2015;28(6):474-485. doi:10.1089/jamp.2015.1223 8. Crowder TM. Highly reproducible pow- der aerosolisation for lung delivery using pow- der-specific electromechanical vibration. Expert Opinion on Drug Delivery. 2005;2(3):579-585. doi:10.1517/17425247.2.3.579 9. Federico MJ, McFarlane AE, Szefler SJ, Abrams EM. e impact of social determinants of health on children with asthma. e Journal of Allergy and Clinical Immunology: In Practice. 2020;8(6):1808- 1814. doi:10.1016/j.jaip.2020.03.028 10. Yaghoubi M, Adibi A, Safari A, FitzGerald JM, Sadatsafavi M. e projected economic and health burden of uncontrolled asthma in the United States. American Journal of Respiratory and Criti- cal Care Medicine. https://www.atsjournals.org/doi/ full/10.1164/rccm.201901-0016OC 11. Soremekun S, Heaney LG, Skinner D, Bulathsin- hala L, Carter V, et al. Asthma exacerbations are asso- ciated with a decline in lung function: A longitudinal population-based study. orax. 2023;78(7):643- 652. doi:10.1136/thorax-2021-217032 12. Farkas D, Bonasera S, Bass K, Hindle M, Lon- gest W. Advancement of a positive-pressure dry powder inhaler for children: Use of a vertical aero- solization chamber and three-dimensional rod array interface. Pharmaceutical Research. 2020;37(9):177. doi:10.1007/s11095-020-02889-7 13. Bass K, Farkas D, Hassan A, Bonasera S, Hin- dle M, Longest PW. High-efficiency dry pow- der aerosol delivery to children: Review and application of new technologies. Journal of Aero- sol Science. 2021;153:105692. doi:10.1016/j. jaerosci.2020.105692 14. Nelson H, Kemp JP, Bieler S, Vaughan LM, Hill MR. Comparative efficacy and safety of albuterol

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