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Markets 6 Industry news 6 Calendar 46 Supplier news 46 Product update Cover 3 TABLETS & CAPSULES packaging Packaging's contribution to patient adherence and cost containment 8 Edward J. Bauer Reese Pharmaceutical brings packaging operation in-house 14 Issue focus: Packaging 16 Pharmapack North America preview 20 The challenges of producing bi-layer tablets 22 Robert Sedlock Relating flow properties to process behavior in tablet presses and capsule filling machines 28 Kerry Johanson Powder transfer & containment: A survey of what's available 33 Eye on Excipients 37 Valdemir Passos Particle size reduction, separation & analysis: A survey of what's available 42 CRS Annual Meeting preview 44 Back Page 48 Steven J. Mead Tablets & Capsules (ISSN 1549-9928 print; ISSN 1938-9159 online) is published eight times a year in January, March, April, May, July, September, October, and November by CSC Publishing, Inc., 1155 Northland Drive, Saint Paul, MN 55120. Periodicals postage paid at Saint Paul, MN, and additional mailing office. POSTMASTER: Send address changes to Tablets & Capsules, 1155 Northland Drive, Saint Paul, MN 55120. departments w w w . t a b l e t s c a p s u l e s . c o m May 2014 Volume 12 Number 4 also in this issue Blister packaging, also called unit-dose packaging, provides a good platform on which to design and build packages that boost patient adherence. But bottles and other containers can also serve that purpose, as a number of startup compa- nies have demonstrated. Learn more about these dif- ferent approaches in the article on page 8. b-TOCFN_1-7_Masters 5/14/14 12:31 PM Page 2