Tablets & Capsules

TC0715

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A 10 July 2015 Tablets & Capsules excipients Starter pellets: Materials, manufacturing methods, and applications Philippe Tschopp Ingredient Pharm This article summarizes the types of starter pellets available, how they are made, and how they are used in the pharmaceutical industry • Reducing the intra- and inter-variability of the dosage form, • Controlling the onset and duration of drug release, • Delivering the active pharmaceutical ingredient (API) to distal sites within the gastrointestinal (GI) tract, • Facilitating fixed-dose combinations forms, • Time-shifting the release of API combinations, e.g., one releasing quickly and the other slowly, • Using a single, basic pellet formulation and varying the dose by changing the number of pellets the tablet or capsule contains, and large variety of starter pellets—also called seeds, beads, nonpareils, micro-granules, and starter cores—can be used in tablets and capsules to meet formulation requirements. Usually, the goal of developing the multi- particulate final dosage form is to establish the desired dissolution profile, target a specific release location or time, and/or mask off-tastes. The benefits of multiparticu- late formulations include:

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