Issue link: https://www.e-digitaleditions.com/i/571156
48 September 2015 Tablets & Capsules resolve old and new difficulties in for- mulating pharmaceutical tablets. T&C References 1. Omyapharm FCC from Omya Inter- national, Oftringen, Switzerland. 2. Preisig D., Haidi D., Varum F.J., Bravo, R., Alles R., Huwyler J., and Puchkov, M. Drug loading into porous calcium carbonate microparticles by solvent evaporation. Eur J Pharm Biopharm, 2014 Aug;87(3):548-58 doi: 10.1016/j.ejpb.2014.02.009. 3. Stirnimann T., Atria S., Schoelkopf J., Gane P.A., Alles R., Huwyler J., and Puchkov M. Compaction of function- alized calcium carbonate, a porous and crystalline microparticulate material with a lamellar surface. Int J Pharm 2014 May 15;466 (1-2): 266-75 doi: 10.1016/j.ijpharm.2014.03.027. 4. Stirnimann T., DiMaiuta N., Gerard D.E., Alles R., Huwler J., and Puchkov, M. Functionalized calcium carbonate as a novel pharmaceutical excipient for the preparation of orally dispersible tablets. Pharm Res 2013 Jul;30(7): 1915-25 doi: 10.1007/s11095-013- 1034-3. 5. Hattler L. et al. Unpublished data. Carolina Diaz Quijano, Ph.D., is techni- cal service and innovation manager for pharmaceutical applications and a senior scientist at Omya International, Basler- strasse 42, CH-4665 Oftringen, Switzer- land. Tel. +41 62 789 2274. Website: www.omya.com. She previously worked as a research collaborator in protein engineering at the University of Zurich and in diagnos- tics and genetic profiles at Stab Vida in Por- tugal. She earned a Ph.D. degree in life sci- ences from ETH Zurich and a licentiate degree in biotechnology and molecular biol- ogy from the University of Buenos Aires in Argentina. Figure 5 Disintegration of orally dispersible granules (ODGs) and an ODT formulated with FCC [3] b. ODT manufactured with ODGs and 10 percent (w/w) caffeine. It disintegrated in 10 seconds. a. ODGs produced by dry granulation from a mixture of FCC and 3 percent (w/w) of disintegrant with a PSD of 180 to 720 microns. The ODGs disintegrated in 2 seconds. 2 seconds 10 seconds