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s e l u s ap C s u l P ® s p a Vc al u q e d te a e r c e r s a e l u s p a l c l t a o N e 24 subjects nophen Human Capsules Vcaps Plus Capsules Gelatin to Gelatin . al u q e d te a e r c o The new standard in HPMC c Immediate release iv v in-vivo perf bioequivalent to gelatin and co dissolution across changing pH ionic strength. Vcaps ® Plus capsules can optimize capsule disinte apsules: formance onsistent H and gration for pharmaceutical cross-over study in 24 subjects Molecule = Acetaminophen Human 8000 7000 6000 5000 4000 3000 2000 n Plasma Acetaminophen Concentration (ng/mL) Proven Bioequivalence o p p p p g r p products with the ability to release contents independent of pH and ionic strength of the test media. An viv in- vo study demonstrates that Vcaps Plus capsules are equivalent to gelatin in terms of human pharmacokinetics profile. Finally, a superior specialty polymer capsule with proven gelatin-like performance without cross-linking potential, Vcaps Plus is the new capsule standard with benefits of narrow weight variability, impressive resistance to heat and humidity, and validated manufacturing experience. By reducing variability, Vcaps Plus capsules are quickly becoming a powerful tool to reduce timelines in drug product development. Contact us at 800-845-6973 for our full technical package and samples for your development review. v vi In- ivo results comparing Vcaps Plus HPMC Capsules and gelatin capsules demonstrate bioequivalency of HPMC in multiple dissolution profiles. vo o pH 1.2 – 9 g KCI/L pH 1.2 – 2 g KCI/L Simulated milk fluid pH 6.8 JP2 pH 6.8 USP % Caffeine dissolved Time in minutes 0 10 20 30 40 50 60 70 80 90 100 pH 1.2 USP 0 3 6 9 12 15 18 21 24 27 30 35 40 45 50 55 60 75 r t In-vitro dissolution of caffeine in Vcaps Plus capsules True pH and Ionic Media Independence 1000 12 10 8 6 4 2 0 0 Nominal Hours (hrs) Post Dose Mean Mean v in-vi o acetaminophen plasma concentration profiles over 12 hours. Copyright © 2017 Lonza. All Rights Reserved. p p Read the full report at VcapsPlus.com.