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i lify enteric drug delivery implementation TING A FOR CO TE TH ELIMINA APSULE TEC Intrinsically enteric capsule technologies CAPSULE TEC C Y LY ENTERIC INTRINSICALL i l t ti ule technologies G E NEED OGIES CHNOLOGIES CHNOL Y ENTERIC . s e s s e c o r g p n i t a c co i r e t n e q s l n m o \ h b ] a n ] \ b p i l j m ] b ` i e i h a [ ] n N . n o i t p r abso um m i x a m e v e i h c a o t n i at t i r ir m o r f h ac m o t s he t g in t c e t o r p o r f e l u c e l mo e v i t i ns e s a g in t c e t o r p r a h p o i b he t in s ge n e l l a h c n mo m o C manufacturing. from development to commercial simplify enteric drug delivery implementation n ] p b n X h l ] n e X ] e Z X b p n m l Ƅ ] a n a n b q e ul s ap c c i r e t n e y l al c i s n i r t n i w o as e l e r he t g in y a l de o , s I P A g n r , t n me n o ir v n e c idi ac he t m de u l inc r t s u d in l a c i t u e ac m r y mmercial very implementation i n e E j g o b \ ] g [ b \ b [ = 100 90 80 Ϋ ] n X b \ ] g g F . s m r o f e sag o d e s a e l e r c i r e nt e P US d an , se e apan J , an e p o ur E h t i w c i s o ul l l e c o s e d a gr al c i t u e c a m ar h p f s e ul s ap c c i r e t n e l al c i s n i r t n i se e h T y d i ac l h ig h r o f e as e l e r d e y a l de d n a y o r o p n t w o h n s e e s b a h y g olo n h c e T u o p m f co e o g n a r a r e v n o o i t c e t o r p n a ro t i - n i v n e v o r p e ar d an s e ul s ap c ] l h b ] g i [ m ] e o m j X [ c eri t n E s® p a c V r o f s h ap gr o n o m a i e p o c a m ar h P p m o c d an , s e v i t a v i r e d c i r e t n e c d se u l e d i w o e d a m e ar f y . ns io at c i l p p a I P A e v i t i ns e s - d n o i t c e t o r c p i r e t n e e d i v o er v li e D g ru c D TM i s in R T en . s d n c i r e t n e e d i v o r o p t vo i - n i v d n \ l X a ] [ ] b j i q n e e Ƅ ϒ i n ϒ s \ X ] r y l p y 9 60 30 0 0 m l o i a h b 10% release h X a n m m ] I a n b q \ ] e e Ƅ ] u b m dissolution testing of V In-vitro % API dissolved 80 70 60 50 40 30 20 10 270 240 210 180 150 120 0 Ϋ E j l ] Ƃ o > ] n X a j m i a M Λ m ] n o h b g h b Ζ h X a n m m ] e n i K Κ release at pH 6.8 m se h ] a j i h b g X n ] [ X Κ F M = ] [ h ] l ] ^ ] l ] l o j a ® Enteric capsule caps tion testing of V j Time in min. ] ] e d 300 Ζ 8 Λ h le . y r e v li e d al r o e l ab n e l al tu c a an c y a c i s n i r t n i , s e tur a r e p m e t n o i t a c li p ap p y d t n a t s h t i t w o n n a t c u n b o i t c e t o r p e v i t i s n e y s l h g i f h e o s a e c h n t d i n A e d p y t o t o r d p i p a r r o d f e z i l i t e u n b a c y l l a c i ins r t in , t n me p o l e v de s s e c o r p n n e o p y u c n e d n e p e g d n i v o m e y r B e i g o l o hn c e t e ul s ap c c i r e t n e y l al r o / d n s a n o i t u l o g s n i t a l co a c i p c i r e t n e e r i u q e t r a h s t e l u c e l o m . p u - e l a c d s n t a n e m p o l e v e d s e gi o l no h c e t e l u ps a c c i r e t n e d n t a c u d o r g p n i t a c co i r e t s e ] l ^ l o i s n m ] o k ] l i n l i ή m ` h b l ] Ƃ i other intrinsically enteric capsule For more information on this an m h i b n b \ h i [ M P R i n ` h b \ l i [ [ X j Κ j ? l o i s solutions@c +33 3 89 2 call S ^ i ] e j g X m ` Ϋ ] p b n X n h ] m ] l j ] l e ] ` o m j X ? or contact com capsugel. e b X g ] ή 20 57 25 (Europe) r o .S.) 800-845-6973 (U ή m ] e o m j X [ [ b l ] n h A ϻ m j X [ S s k ή Copyright © 2017 Lonza. All Rights Reserved.