2017 Bulletin

Fall Issue

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Bulletin vol. 31 no. 2 | 27 Dr. Robert Stern received his PhD in Clinical Psychology from the University of Rhode Island. He completed his predoctoral internship training under Dr. Edith Kaplan at the Boston VA Medical Center and his post- doctoral fellowship at the University of North Carolina School of Medicine. He is currently Professor of Neurology, Neurosurgery, and Anatomy & Neurobiology at Boston University (BU) School of Medicine, where he is also Director of the Clinical Core of the NIH-funded BU Alzheimer's Disease Center, and Director of Clinical Research for the BU Chronic Traumatic Encephalopathy (CTE) Center. A major focus of his research involves the long-term effects of repetitive head impacts in athletes, including the neurodegenerative disease, CTE. He is the lead co-principal investigator of a $16 million NIH grant for a multi-center, longitudinal study to develop methods of diagnosing CTE during life as well as examining potential risk factors of the disease. Dr. Stern's other current major area of funded research involves the diagnosis and treatment of Alzheimer's disease. He has published on various aspects of cognitive assessment and is the senior author of the Neuropsychological Assessment Battery (NAB), as well as the Boston Qualitative Scoring System for the Rey-Osterreith Complex Figure. He has received numerous NIH and other national grants and he is a Fellow of both NAN and the American Neuropsychiatric Association. Dr. Stern has over 175 peer-reviewed publications, is on several journal editorial boards, and is the co-editor of two upcoming books: Sports Neurology (part of the Handbook in Clinical Neurology series published by Elsevier), and The Oxford Handbook of Adult Cognitive Disorders. He is a member of the medical advisory boards of several biotech/pharma companies as well as the Mackey-White Health and Safety Committee of the NFL Players Association and the Medical Scientific Committee for the NCAA Student-Athlete Concussion Injury Litigation. References 1. McKee, A. C., Stern, R. A., Nowinski, C. J., et al. (2013). The spectrum of disease in chronic traumatic encephalopathy. Brain, 136(Pt 1), 43-64. doi:10.1093/brain/aws307 2. Mez, J., Daneshvar, D. H., Kiernan, P. T., et al. (2017). Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football. JAMA, 318(4), 360-370. doi:10.1001/jama.2017.8334 3. Stern, R. A., Daneshvar, D. H., Baugh, C. M., et al. (2013). Clinical presentation of chronic traumatic encephalopathy. Neurology, 81(13), 1122-1129. doi:10.1212/WNL.0b013e3182a55f7f 4. Montenigro, P. H., Alosco, M. L., Martin, B. M., et al. (2017). Cumulative Head Impact Exposure Predicts Later-Life Depression, Apathy, Executive Dysfunction, and Cognitive Impairment in Former High School and College Football Players. J Neurotrauma, 34(2), 328-340. doi:10.1089/ neu.2016.4413 5. Omalu, B. I., DeKosky, S. T., Minster, R. L., Kamboh, M. I., Hamilton, R. L., & Wecht, C. H. (2005). Chronic traumatic encephalopathy in a National Football League player. Neurosurgery, 57(1), 128-134; discussion 128-134. 6. Alosco, M. L., Kasimis, A.B., Stamm, J.M., Chua, A.S., Baugh, C.M., Daneshvar, D.H., Robbins, C.A., Mariani, M., Hayden, J., Conneely, S., Au, R., Torres, A., McClean, M.D., McKee, A.C., Cantu, R.C., Mez, J., Nowinski, C.J., Martin, B.M., Chaisson, C.E., Tripodis, Y., Stern, R.A. (2017). Age of First Exposure to American Football and Long-Term Neuropsychiatric and Cognitive Outcomes. Translational Psychiatry. 7, e1236; doi 10.1038/ tp.2017.197 7. Stamm, J. M., Bourlas, A. P., Baugh, C. M., et al. (2015). Age of first exposure to football and later-life cognitive impairment in former NFL players. Neurology, 84(11), 1114-1120. doi:10.1212/ WNL.0000000000001358 8. Stamm, J. M., Koerte, I. K., Muehlmann, M., et al. (2015). Age at First Exposure to Football Is Associated with Altered Corpus Callosum White Matter Microstructure in Former Professional Football Players. J Neurotrauma, 32(22), 1768-1776. doi:10.1089/neu.2014.3822 9. Alosco, M. L., Mez, J., Kowall, N. W., et al. (2017). Cognitive Reserve as a Modifier of Clinical Expression in Chronic Traumatic Encephalopathy: A Preliminary Examination. J Neuropsychiatry Clin Neurosci, 29(1), 6-12. doi:10.1176/appi.neuropsych.16030043 10. Stein, T. D., Alvarez, V. E., & McKee, A. C. (2015). Concussion in Chronic Traumatic Encephalopathy. Curr Pain Headache Rep, 19(10), 47. doi:10.1007/s11916-015-0522-z 11. Bieniek, K. F., Ross, O. A., Cormier, K. A., et al. (2015). Chronic traumatic encephalopathy pathology in a neurodegenerative disorders brain bank. Acta Neuropathol, 130(6), 877-889. doi:10.1007/s00401-015-1502-4 12. Ling, H., Morris, H. R., Neal, J. W., et al. (2017). Mixed pathologies including chronic traumatic encephalopathy account for dementia in retired association football (soccer) players. Acta Neuropathol, 133(3), 337- 352. doi:10.1007/s00401-017-1680-3 13. Montenigro, P. H., Baugh, C. M., Daneshvar, D. H., et al. (2014). Clinical subtypes of chronic traumatic encephalopathy: literature review and proposed research diagnostic criteria for traumatic encephalopathy syndrome. Alzheimers Res Ther, 6(5), 68. doi:10.1186/s13195-014-0068-z 14. Stern, R. A., Tripodis, Y., Baugh, C. M., et al. (2016). Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy. J Alzheimers Dis, 51(4), 1099-1109. doi:10.3233/JAD- 151028 15. Alosco, M. L., Tripodis, Y., Jarnagin, J., et al. (2017). Repetitive head impact exposure and later-life plasma total tau in former National Football League players. Alzheimers Dement (Amst), 7, 33-40. doi:10.1016/j. dadm.2016.11.003

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