Tablets & Capsules


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Tablets & Capsules March 2018 23 A PI molecules intended for oral administration are often categorized using the Biopharmaceutical Classification System (BCS), which indicates the primary factors affecting API bioavailability and, subsequently, directs the formulation strategy required to support the drug product's development. The system uses the API's solubility and permeability characteristics to place the compound into one of four categories, as shown in Figure 1. The prevalence of poorly soluble active pharmaceutical ingredient (API) molecules in the drug development pipeline has increased the popularity of solubility-enhancing formulations for oral tablet drug products. This article discusses the benefits of creating spray-dried dispersions to improve API solubility. Creating spray-dried dispersions to improve API solubility Nikki Whitfield Quotient Sciences formulation

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