Issue link: https://www.e-digitaleditions.com/i/962670
40 April 2018 Tablets & Capsules for API absorption. However, these materials are not readily water soluble, and for many solid dosage forms, fast dissolution in aqueous media is a decisive requirement. For example, with chewable or compressed lozenge tablets, where taste and texture play an important role, a water-soluble filler- binder with pleasant organoleptic properties is the excipient of choice. Isomalt is a common example of such a filler-binder. In comparison to other polyols, isomalt offers a remarkable sensorial profile, including a sugar-like sweet taste and a pleasant mouth feel. It is non-cariogenic and has a low glycemic index. Companies frequently use isomalt to manufacture powder sachets, compressed lozenges, and chewable and effervescent tablets due to its high compactability and ease of use [5]. The study described here evaluated a direct compression type of isomalt to determine its suitability as a solid absorbent for liquisolid formulations. Materials and methods The materials used in the study are listed in Table 1. Chewable t a b l e t s w e r e m a n u f a c t u r e d b y blending the isomalt with 7 percent by weight (w/w) of each liquid component using a high-shear Figure 3 Tablet hardness as a function of compression force (Error bars indicate standard deviation) 4.0 6.0 8.0 10.0 12.0 14.0 galenIQ 721 + simethicone Q7-2243 LVA galenIQ 721 + linseed oil galenIQ 721 + simethicone antifoam C100EP Compression force (kilonewtons) Tablet hardness (newtons) 120 110 100 90 80 70 60 50 40 Figure 2 SEM image of isomalt (galenIQ 721) NBE Private Label Oral Care • NBE Efferdent • NBE Polident NBE Polident NBE Polident OTC Drugs • NBE Alka Seltzer • NBE Alka Seltzer Plus Contract Manufacturing OTC • Supplements • Beverages Beverages Beverages • Cosmetics Cosmetics Cosmetics • Shower & Bath tablets Shower & Bath tablets Shower & Bath tablets • Tablets, Powders & Granulations Tablets, Powders & Granulations Tablets, Powders & Granulations Dietary Supplements ❖ In House Testing & Product Development Humidity Controlled Environment ❖ Humidity Controlled Environment www.towerlabs.com • Phone (860) 767-2127 • Centerbrook, CT • Clinton, CT • Montague, MI NBE Private Label Oral Care • NBE Efferdent ® • NBE Polident ® OTC Drugs • NBE Alka Seltzer ® • NBE Alka Seltzer Plus ® Dietary Supplements • NBE Airborne ® Contract Manufacturing OTC • Supplements • Beverages • Cosmetics • Shower & Bath tablets • Tablets, Powders & Granulations ❖ In House Testing & Product Development ❖ Humidity Controlled Environment ❖ FDA Registered & cGMP Compliant NBE Airborne Humidity Controlled Environment ❖ FDA Registered & cGMP Compliant NBE Airborne NBE Airborne FDA Registered & cGMP Compliant www.towerlabs.com • Phone (860) 767-2127 • Centerbrook, CT • Clinton, CT • Montague, MI Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements 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