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Tablets & Capsules April 2018 43 Oliver Luhn is head of pharmaceutical technology and Joerg Bernard is head of food and non-food technology at Suedzucker AG, Wormser Strasse 11, 67283 Obrigheim (Pfalz), Germany (www.suedzucker.de, 49 621 421 0). Michael Black is head of sales for pharma and Maj-Britt Cepok is product manager for pharma at Beneo-Palatinit GmbH, Maximilianstrasse 10, 68165 Mannheim, Germany (www.beneo. com, 49 621 421 150). Pandurang N. Dhabale, and Satish B. Bhise, "Dissolution rate enhancement of fenofibrate using liquisolid tablet technique," Latin American Journal of Pharmacy, Vol. 28, pages 219-225, (2009). 3. K.A. Khaled, "Formulation and evaluation of hydrochlorothiazide liquisolid tablets," Saudi Pharmaceutical Journal, Vol. 6, pages 39-46, (1998). 4. Spiridon Spireas, "Liquisolid systems and methods of preparing same," US patent No. 6423339B1, (2002). 5. Gerad K. Bolhuis, Erik G. Rexwinkel, and Klaas Zuurman, "Polyols as filler-binders for disint- egrating tablets prepared by direct compaction," Drug Development and Industrial Pharmacy, Vol. 35, No. 6, pages 671-677, (2009). 6. Bettina Zielasko, Ermittlung physikalisch-chemischer Daten von Isomalt und seinen Komponenten, PhD thesis, University Braunschweig, page 51, (1997). equipped with a force feeder. The tablet hardness yield was excellent. Both tablet mass uniformity and f r i a b i l i t y c o m p l i e d w e l l w i t h pharmacopoeial standards. Formulators must be aware that limitations in blend flowability and compactability will quickly arise once the liquid component in the liquisolid exceeds a certain concentration. In such cases, it's recommended that the isomalt be blended with one of the more porous carrier excipients mentioned in this article's introduction. This will allow the tablet to maintain the excellent sensorial properties of the isomalt but improve absorption. T&C References 1. Y. Javadzadeh, B. Jafari- Navimipour, and A. Nokhodchi, "Liquisolid technique for dissolution rate enhancement of a high dose water insoluble drug (carbamazepine)," International Journal of Pharmaceutics, Vol. 341, No. 1-2, pages 26-34, (2007). 2. Amrit Karmarkar, Indrajeet D. Gonjari, Avinash H. Hosmani, Contact Kyle Myers kmyers@cscpub.com