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Finally, ask for references to determine if the manufac- turer has the experience and resources necessary to deliver your product. For example, if you're creating a product for mass-market distribution, the manufacturer should know the regulations for labeling and shelf-life. 10. Can the CDMO scale to your distribution and prod- uct launch requirements? It is imperative to visit the manufacturing facility and meet the team responsible for production, including the business development executive and scientific formulators. Verify that the manufacturer can meet your production- volume requirements. If the most a CDMO has ever made is 5 million units and you plan to order 100 million units, can the manufacturer handle it? What is its surge capacity? The manufacturer should demonstrate its record of suc- cess working on similar types of products. T&C References 1. Supplements/OTC/Rx Consumer Report, 5th Ed. Natural Marketing Institute. 2015. 2. Global New Products Database, Region: Canada and US. Mintel. 2016 3. Which drug forms do patients and physicians pre- fer? Capsugel. 1981. 4. Licaps Fusion from Capsugel, Greenville, SC. 5. Band-sealing research and development study. Capsugel, Colmar, France. September 2005. 6. Amo, R. DRcaps capsules achieve delayed release properties for nutritional ingredients in human clinical study. Capsugel-commissioned study conducted by Bio- Images Research, Glasgow, Scotland. 2014. 7. CoQ10 study. Capsugel-commissioned study con- ducted by Accutest Research Laboratory, Mumbia India. 2005. Further reading Find more information about liquid-filled capsules in the article "Filling two-piece hard gelatin capsules with liquids," by Matt Richardson and Sven Stegemann. It appeared in the January 2007 issue. Another article by Keith Hutchinson and Anthony Macci, "Advances in manufacturing liquid-filled hard cap- sules for delivery of difficult APIs," appeared in the September 2013 issue. Find more information in Tablets & Capsules' article index in the November 2016 issue and at T&C's website, www.tabletscapsules.com. Stan Glab is manager of product development and formulations, and Missy Lowery is senior manager of marketing at Capsugel, now a Lonza company, 535 North Emerald Road, Greenwood, SC 29646. Tel. 888 783 6361. Website: www.capsugel.com. Tablets & Capsules October 2017 32E ed further do down the GI tra then deliver n de the low th w pH f stomach acid; the act t viable a keeps th supplement via e as it adds p obioti k ps th the supplemen ics, the e E o E or pr n the case of SAM-E In oving ng the experien e consumer upset, u et, impr fect f fish burbs or stomach the adverse "side ef ffects" of fish burbs or stomach eppermint extracts, an enteric coating masks pep acts, an enteric coating masks or peppermint extracts, an enteric coating masks oducts like fish oils, garlic concentrates, sh oils, garlic concentrates, ith h pr W pr om stomach acid. W ed dient fr the suppleme ement/ingr edient, or o t om the acti e ingr onsum fr ot mer fr con e utilized to either pr ations, ar appl plications, ar c systems in dietary supplement, or user Ente eric s in dietary supplement, or user taking ex psule t xperience for the consumer cap ele coating that enhances elease c elayed r , Nutritional Enteric Coating System, is a del ® Nutrateric he a e ef N e active pH of the sto utritional Enteric Coating System, is a supp ects" of fi mer edient is e it can act wher ive ingr om otection fr pr enteric coating nce. or stomach ting masks centrates, ach acid. otect to pr tect the t, or user . sumer s the tablet/ System, is a e upplier of Choic S r u o Yo y ly a ra N g e to Coatin r Co m o r F atur ll oven t con.com .color w esent epr www con r Con ntact your local Color use with both soft gel and two-piece for both soft gel and t Nu c is easy to apply and p trateric d pr ov e the maximum benef ovide efit. pr ed further do own the GI tra n d deliver then Y fective d gelatin capsules tative to find out more. e har ffective e it can act wher to be highly ef e upplier of Choic S r u o Yo y ly a ra Natur ll Y