Issue link: https://www.e-digitaleditions.com/i/1022930
14 September 2018 Tablets & Capsules The survey was open to all IQ Consortium member companies. For member companies with multiple R&D facilities, each facility could submit a response. The group received twelve responses from eleven different companies including: AbbVie, Amgen, Biogen, Boehringer Ingelheim, Bristol-Myers Squibb, Eli Lilly and Company, GlaxoSmithKline, Merck and Company, Merck KGaA, Pfizer, and Vertex. All responses were ano- nymized by the IQ secretariat, and the aggregated results were provided to the CSWG for analysis. The survey contained a combination of multiple-choice, open/free-field, rank-order, and scale-based questions. For example, "On a scale of 1 to 5, score each option on its effectiveness to mitigate sticking." To compare the options within a given scale-based question, the results were nor- malized to account for the number of responses (not every question received twelve responses), and the options were ranked based on their final, normalized values. A brief note on terminology When referring to material adherence to compression tool faces, tableting professionals often use terminology inconsistently or interchangeably, which may lead to confusion. To avoid such confusion, the survey used the word "sticking" as a comprehensive term for any unwanted material adherence to the compression tool face, including "picking" and "filming," unless stated oth- erwise. The same is true for this article. Compression Sticking Working Group (CSWG) to pro- vide a venue for members to discuss the topic of tablet sticking and, in doing so, create awareness of research that has already been conducted and identify directions for future studies. The CSWG initially set out with two primary goals: 1) To review published literature to determine the cur- rent state of the art with respect to tablet sticking; and 2) To survey tablet manufacturers to identify trends and potentially create opportunities for collaboration. The first goal was achieved through the publication of a com- prehensive literature review that provides a summary of recent advancements related to the field [1]. The second goal was accomplished through a survey of IQ Consortium member companies, the results of which are summarized in this article, which is intended to provide insight into the problem and highlight opportunities for future advancement. About the survey The survey consisted of 30 questions and focused on five themes related to sticking: 1. Prevalence and occurrence 2. Predictive tools and modeling 3. Drug substance properties 4. Formulation properties 5. Process and equipment The solution to your Solid Dosage needs Specialty Measurements Inc. Website: www.smitmc.com Phone: +1 (908) 534-1500 R&D to Pilot Scale Production Monolayer & Bilayer Tablet Presses Advanced Data Acquisition & Analysis System Excellence in Quality & Service