Issue link: https://www.e-digitaleditions.com/i/1101841
Tablets & Capsules April 2019 15 tors, and fluidized-bed systems, from different manufac- turers. As a result, user-friendly human machine interfaces (HMIs) are becoming increasingly important, and clearly arranged, intuitive interfaces for operating elements with distinct graphical representations are obligatory. Conclusion As in many industries, cost pressures in the pharma- ceutical industry continue to increase, driving efforts to improve process efficiency and reduce production times. These concerns affect all pharmaceutical manufacturing processes but are particularly important for tablet coating, which can be very costly in terms of time and energy use. Production coating units must be increasingly flexible to handle tablets with diverse formulations, shapes, and sizes, as well as capsules and pellets, with a wide range of different coating solutions. Coating processes also require flexibility with respect to fill level to meet the require- ments of varying batch sizes and products. Finally, the number of highly potent formulations is growing, requir- ing manufacturers to implement suitable precautionary and containment measures while keeping in mind the associated costs. Moving toward more completely auto- mated coating processes will help manufacturers meet these demands while maximizing the efficiency and reproducibility of their coating processes. T&C Torsten Meinel-Dirumdam is product manager for coater series type LC at Lödige Process Technology, Paderborn, Germany (+49 5251 3090, dirumdam@loedige.de, www.loedige.de). To clean the coater as quickly and as cost-effectively as possible, minimize the number of cleaning nozzles and optimize their cleaning effect. This includes controlling and adjusting the spray pressure, temperature, and concen- tration of the cleaning medium as well as appropriately spacing the cleaning nozzle from the surface to be cleaned. An efficient coating unit must have controls for all functions and control circuits and must guarantee repro- ducibility of the coating and cleaning processes in fully automatic mode, even for complex units. Data exchange via all interfaces with higher-ranking or parallel systems is necessary to ensure gap-free process documentation and error analysis. Conformity with good automated manufac- turing practice (GAMP) and 21 CFR part 11 are standard. Equipment operators are frequently required to operate various equipment types, such as coaters, mixing granula- Figure 7 Three-dimensional cleaning nozzle on production coater spray arm Cleaning nozzle FloZein Products ● +1.978.827.5101 ● info@flochemicalcorp.com ● www.zeinproducts.com FloZein Products Vegan Coatings ENTERIC COATING ● EXTENDED RELEASE ● MICRO & NANO ENCAPSULATION ANTIMICROBIAL ● OXYGEN & MOISTURE BARRIER ● TASTE MASKER EXCIPIENT ● ENCAPSULATION OF ACTIVE INGREDIENTS Zein is more than just a direct replacement for pharmaceutical glaze and other coating materials. Our VEGAN FloZein products offer a wide range of applications for pills, capsules and tablets. Zein is manufactured using the proprietary Freeman process to guarantee consistent high quality product. All FloZein products are: All-natural, VEGAN, & GMO Free USP/NF monogram compliant (pharma grade) Ⓤ Kosher (parve) & Halal compliant Digestible & Biodegradable Identified as a GRAS food product by the USFDA Non-reactive with active ingredients Clean Label; no additives or preservatives Gluten-, lactose-, and Sugar-free