Tablets & Capsules


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Tablets & Capsules October 2019 27 A JRS Pharma Formulation effects on tablet surface properties and film coating adhesion excipients This article is based on the master thesis "Investigation of the influence of functional excipients for tablet cores on the quality of applied coatings," by Martin Wewers under the direction of Dr. Jan Henrik Finke at the Technical University of Braun- schweig, in Germany. The study was conducted at the univer- sity's Institute for Particle Technology (iPAT) and at JRS Pharma, in Rosenberg, Germany. queous film coatings can enhance the appearance, sta- bility, swallowability, and brand identity of pharmaceu- tical tablets. Coatings can also be used to mask the taste of a bitter or otherwise unpleasant active pharmaceutical ingredient or control its release. The properties of the tablet being coated, including tensile strength, surface roughness, and hydrophobicity can greatly influence coating quality and performance. This article describes a study conducted to investi- gate the influence of different commonly used lubricants and disintegrants on tablet surface roughness and film coating adhesion. In addition, a commercially available coprocessed excipient for direct compression (Prosolv Easytab) containing silicified microcrystalline cellulose (SMCC), lubricant, and disintegrant was part of the study. The study investigated the influence of two lubri- cants, magnesium stearate (MgSt) and sodium stearyl fumarate (SSF), and three disintegrants, croscarmellose sodium (CCS), crospovidone (PVPP) and sodium starch glycolate (SSG). The researchers prepared tablets of pure microcrystalline cellulose (MCC), five physical mixtures containing MCC and either disintegrant or lubricant, and the coprocessed excipient. The tensile

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