Issue link: https://www.e-digitaleditions.com/i/1173734
Tablets & Capsules October 2019 32C Customized Fill Release in Gelatine Soft Capsules Revolutionary Release Fast release and reduced cross-linking Reliable Release Reduced cross-linking Standard Release Improved shelf-life and stability Release profile Enteric Release One-step-production of truly enteric capsules GELITA USA · Sioux City, IA · www.gelita.com · service.na@gelita.com capsules, following specific setup parameters to open the empty capsule shells, create slugs of powder formulation, insert the slugs into the capsule bodies, then close, lock, and eject the filled capsules. The specific method used to create the slugs of formulation can be adapted depend- ing on the application. When working with nutraceutical ingredients, such as vitamins, botanicals, herbs, and nat- ural extracts, a tamping-style machine is often preferred because it is best equipped to handle the inherent vari- ance in nutraceutical ingredient properties. CDMOs working with brand owners can further support the manufacturing process by consulting with customers when selecting equipment for unique formu- lations. Beyond equipment selection, they can also carry out maintenance evaluations, inspecting the machinery and tooling for damage or wear. Tooling inspections are essential to delivering the best results, as the tooling on a capsule-filling machine is critical for creating the pow- der slugs and aligning them with the empty capsules for insertion, and worn tooling can increase downtime and reduce yields. CDMOs and suppliers can also enhance capsule-fill- ing productivity by delivering comprehensive, end-to- end service. Process improvement programs, for instance, which assess current practices, processes, and yields, provide manufacturers with a tailored toolkit for nav- igating enhancements in overall yield. This includes evaluating and optimizing machine speeds to increase provide support throughout the process, offering brand owners expertise and guidance during R&D and formula- tion, helping to determine release profiles, select capsules and polymers, and source high-quality raw materials to deliver the desired results. Sourcing the highest quality raw materials and ensur- ing that they are tested for identity, purity, safety, and effectiveness is essential for shaping the success of a finished capsule product, as a product is only as good as the materials used to make it. Additionally, knowing the source of ingredients is very important to 43 percent of US consumers [2]. Collaborating with reliable and trusted suppliers helps to create optimal manufactur- ing conditions and minimize the risk of material-related problems occurring during processes such as capsule filling. This improves lead-time performance, reduces required inventory levels and costs, and frees up working capital for the manufacturer. A careful consideration After selecting all the raw materials, including the cap- sule dosage form, manufacturers must carefully consider their choice of capsule-filling equipment. A variety of machines, equipment, and operational processes are used for capsule filling. Taking the time to choose the right machine for each production line plays a large role in maintaining product quality, enhancing yields, and realiz- ing profitablilty. An encapsulation machine handles hard