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Tablets & Capsules October 2019 49 oxides that could degrade perox- ide-sensitive APIs. More data with different APIs and doses are neces- sary to be able to make valid gen- eral predictions; however, this study provides useful insight into the types of benefits each dry binder brings to either high-dose or medium-dose API-containing DC formulations. T&C Table 2 Summary of the effects of adding dry binders to 10% piroxicam and 90% NCC DC formulations (85% NCC after addition of 5% dry binder) Compactability Friability Disintegration time Dissolution DCP DC + 10% piroxicam Omyapharm + 0 0 0 Copovidone + 0 - -- MCC DC + 10% piroxicam Omyapharm ++ ++ 0 ++ Copovidone ++ ++ -- ++ Lactose DC + 10% piroxicam Omyapharm ++ ++ ++ 0 Copovidone ++ ++ ++ -- 85% NCC DC Omyapharm ++ ++ + Not measured Copovidone ++ ++ -- Key 0 no effect - marginally negative -- significantly negative + marginally positive ++ significantly positive References 1. A. G. Mirani, et al., " Direct compr e ssion high f u nc t ionalit y excipient using coprocessing tech- nique: A brief review," Current Drug Delivery, 2011, Vol. 8, No. 4, pages 426-435. 2 . G r egor y T hoor ens, et al., "Microcrystalline cellulose, a direct compression binder in a quality by desig n environment — A review," Int e r n atio n al Jo ur n al of Phar m ace u- tics, 2014, Vol. 473, No. 1-2, pages 64-72. 3. Z h e L i, e t a l., " C o mp o s- it e p a r t icle s b a s e d on p a r t icle eng inee r ing for d ir ec t compac- tion," Inter national Jour nal of Phar- maceutics, 2017, Vol. 519, No. 1-2, pages 272-286. 4. John Rojas, "Excipient design by co-processing for direct com- pression applications," In: Ajit S. Narang, H.S. Boddu (eds.) Excipient Applications in Formulation Design and Drug Delivery, Springer, 2015. 5. Carolina Diaz Quijano, "Eye on Excipients: Functionalized cal- cium carbonate," Tablets & Capsules, September 2015, pages 44-48. 6 . C a r o l i n a D i a z Q u i j a n o , "Directly compressible ODT plat- forms: a comparison study," Tablets & Capsules, July 2018, pages 18-23. Carolina Diaz Quijano (+41 62 789 2274, carolina.diazquijano@omya. com) is head of technical services for consumer goods and Javier Camargo is global business development manager at Omya International (www.omya.com).