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36 March/April 2021 Tablets & Capsules Thomas B. Gold Metrics Contract Services Formulation and manufacturing challenges of multilayer tablets tableting W This article explores the challenges of multilayer tablet for- mulation and the approaches developers can take to overcome those challenges. hile the use of biologics has grown in recent years and has drawn much attention, oral solid dosage forms (OSDFs) remain the pharmaceutical industry's staple. OSDF manu- facturers are continuously innovating and exploring ways to reformulate solid-dose products to renew patents and improve efficacy and patient compliance. Manufacturers are creating effective treatments for an increasing number of major diseases and are gaining a better understanding of comorbidities and the possibilities