Issue link: https://www.e-digitaleditions.com/i/1491587
12 February 2023 Inhalation Figure 1 Epithelial cell transport mechanisms of inhaled products Airflow Mucus Epithelium Transellular transport Paracellular transport Blood flow Figure 2 Commercially available cellular models to target the respiratory system. The models listed in blue are extracted or derived from normal (healthy) subjects and the models listed in red are from diseased subjects. Nasal Cavity: HNEpC RPMI2650 Pharynx: Detriot 562 Larynx: HuLa-PC Trachea: Hs 680.Tr Bronchus: BEAS-2B HBEC3-KT NuLi-1 NL20 NL20-TA HBE4-E6/E7 16HBE14o- ChaGo-K-1 NCI-H727 CuFi-1, 4, 5 and 6 HBE135-E6E7 BBM BZR General Lung/Respiratory Representative Models: Primary Bronchial/Tracheal Epithelial Cells; Normal, Human Primary Small Airway Epithelial Cells; Normal, Human (HSAEC) Primary Lung Fibroblast, Normal, Human (HLF) Primary Lung Smooth Muscle Cells; Normal, Human HSAEC1-KT Primary Lung Fibroblasts (COPD, Asthma, Fibrosis) hTERT Lung Fibroblast HCM-CSHL-0058-C34 HCM-BROD-0449-C34 HCM-BROD-0236-C34 HCM-BROD-0027-C34 Calu-1, 3 NCI-H441 Alveoli: A549 SW1573