2 Pharmaceutical Technology
®
The Real Message Behind Commercial mRNA Products April eBook 2023 PharmTech.com
FROM THE EDITOR
4 The mRNA Message
Chris Spivey
mRNA TRENDS
6 Learning to Think at Lightspeed
Chris Spivey
12 Nucleic Acid-based Therapeutics
Are Stepping into the Spotlight
Feliza Mirasol
DEVELOPMENT
18 COVID-19's Impact on
RNA Drug Development
Marina Necdina
22 Excipients Impact
Stability in mRNA-LNP Formulations
Cynthia A. Challener
DRUG DELIVERY
26 Delivering on the
Potential of mRNA Therapeutics
David Ricketts, Nevin Witman, Phil Challis,
Senne Dillen, and Bernard Sagaert
ANALYTICS
36 The Marriage of RNA
and Mass Spectrometry
Mark Rogers
40 The Role of Separation Techniques
in the Analysis of mRNA Therapeutic
Drug Substances and Drug Products
Christina Vanhinsbergh
STABILITY
50 Managing mRNA Instability During
Formulation, Manufacturing, and Shipment
Cynthia A. Challener
52 Ad Index
Cover image: myboys.me - stock.adobe.com; Cover design, Maria Xelo
The Real Message Behind
Commercial mRNA Products April 2023
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F O U N D E R
Mike Hennessy Sr
1 9 6 0 - 2 0 2 1
EDITORIAL
Editorial Director Chris Spivey CSpivey@mjhlifesciences.com
Senior Editor Felicity Thomas FThomas@mjhlifesciences.com
Managing Editor Susan Haigney SHaigney@mjhlifesciences.com
Science Editor Feliza Mirasol FMirasol@mjhlifesciences.com
Editor Jill Murphy JMurphy@mjhlifesciences.com
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Creative Director, Publishing Melissa Feinen
Senior Art Director Marie Maresco; Senior Graphic Designer Maria Xelo
CONTRIBUTING EDITORS:
Jill Wechsler jillwechsler7@gmail.com; Hallie Forcinio, editorhal@cs.com;
Susan J. Schniepp, sue.schniepp@mac.com; Cynthia A. Challener, PhD challener@vtlink.net ;
and Jennifer Markarian, Manufacturing Reporter.
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